Bioprinting of osteochondral tissues: A perspective on current gaps and future trends
Bioprinting of osteochondral tissues: A perspective on current gaps and future trends
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DOI：
10.18063/ijb.2017.02.00.007
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发表时间：
2017-01-01
影响因子：
8.4
通讯作者：
Ozbolat, Ibrahim T.
中科院分区：
文献类型：
--
作者：
Datta, Pallab;Dhawan, Aman;Ozbolat, Ibrahim T.
骨软骨组织再生一直是骨科手术的一个关键挑战，特别是由于关节机械脱位引起的关节炎变性并发症。自体移植的通用金标准在提出组织工程策略来解决未满足的临床需求方面存在一些局限性。然而。由于关节解剖的复杂性。由于界面组织的不均匀性，传统的组织工程策略存在一定的局限性。生物打印技术的出现为骨软骨组织工程提供了新的机遇。生物打印可以独特地模拟异质性细胞组成和各向异性细胞外基质（ECM）组织，同时允许靶向基因传递以实现异型分化。从这个角度来看，我们讨论了复合骨软骨组织生物打印的当前进展，并提出了在组织整合、长期存活和植入时的机械强度方面的挑战，这些挑战需要解决，以实现生物打印组织的有效临床转化。最后，我们强调了与骨软骨生物打印相关的一些未来趋势，希望能在临床应用中得到应用。
Osteochondral tissue regeneration has remained a critical challenge in orthopaedic surgery, especially due to complications of arthritic degeneration arising out of mechanical dislocations of joints. The common gold standard of autografting has several limitations in presenting tissue engineering strategies to solve the unmet clinical need. However. due to the complexity of joint anatomy. and tissue heterogeneity at the interface, the conventional tissue engineering strategies have certain limitations. The advent of bioprinting has now provided new opportunities for osteochondral tissue engineering. Bioprinting can uniquely mimic the heterogeneous cellular composition and anisotropic extra-cellular matrix (ECM) organization, while allowing for targeted gene delivery to achieve heterotypic differentiation. In this perspective, we discuss the current advances made towards bioprinting of composite osteochondral tissues and present an account of challenges in terms of tissue integration, long-terin survival, and mechanical strength at the time of implantation required to be addressed for effective clinical translation of bioprinted tissues. Finally, we highlight some of the future trends related to osteochondral bioprinting with the hope of in-clinical translation.