Nonclassically Secreted Regulators of Angiogenesis.
Nonclassically Secreted Regulators of Angiogenesis.
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DOI：
10.4172/2329-9495.1000101
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发表时间：
2013-02-28
期刊：
影响因子：
--
通讯作者：
Prudovsky I
中科院分区：
文献类型：
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作者：
Prudovsky I
许多分泌的血管生成多肽调节剂缺乏信号肽。这些蛋白质通过不依赖于内质网和高尔基体的非经典途径释放。在大多数情况下，非经典蛋白质输出是由压力诱导的。它通常用于刺激受损组织的修复或炎症。本文综述了无信号肽的分泌型血管生成调节因子，并讨论了其非常规输出的机制和生物学意义。
Many secreted polypeptide regulators of angiogenesis are devoid of signal peptides. These proteins are released through nonclassical pathways independent of endoplasmic reticulum and Golgi. In most cases, the nonclassical protein export is induced by stress. It usually serves to stimulate repair or inflammation in damaged tissues. We review the secreted signal peptide-less regulators of angiogenesis and discuss the mechanisms and biological significance of their unconventional export.