Rel induces interferon regulatory factor 4 (IRF-4) expression in lymphocytes: modulation of interferon-regulated gene expression by rel/nuclear factor kappaB.
Rel induces interferon regulatory factor 4 (IRF-4) expression in lymphocytes: modulation of interferon-regulated gene expression by rel/nuclear factor kappaB.
复制标题
RER诱导干扰素调节因子4（IRF-4）在淋巴细胞中的表达：通过REL/核因子Kappab对干扰素调节的基因表达的调节。
DOI：
10.1084/jem.191.8.1281
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发表时间：
2000-04-17
影响因子：
15.3
通讯作者：
Gerondakis, S
中科院分区：
文献类型：
--
作者：
Grumont, R J;Gerondakis, S
在淋巴细胞中，Rel转录因子在建立促进细胞增殖、存活和分化的基因表达模式方面是必不可少的。在这里，我们发现有丝分裂原诱导的干扰素调节因子4(IRF-4)的表达是依赖于Rel的，IRF-4是干扰素家族中淋巴特异性的成员。与IRF-4作为干扰素诱导的基因表达抑制因子的作用一致，c-Rel−/−B细胞中IRF-4的缺失与这些细胞对IFN的抗增殖活性更敏感相一致。反过来，强制表达irf-4转基因使干扰素调节的c-Rel−/−B细胞的增殖恢复到野生型细胞的水平。两条不同的信号通路之间的这种交叉调节代表了一种新的机制，即REL/核因子κB可以以细胞类型特异性的方式抑制干扰素调控基因的转录。
In lymphocytes, the Rel transcription factor is essential in establishing a pattern of gene expression that promotes cell proliferation, survival, and differentiation. Here we show that mitogen-induced expression of interferon (IFN) regulatory factor 4 (IRF-4), a lymphoid-specific member of the IFN family of transcription factors, is Rel dependent. Consistent with IRF-4 functioning as a repressor of IFN-induced gene expression, the absence of IRF-4 expression in c-rel −/− B cells coincided with a greater sensitivity of these cells to the antiproliferative activity of IFNs. In turn, enforced expression of an IRF-4 transgene restored IFN modulated c-rel −/− B cell proliferation to that of wild-type cells. This cross-regulation between two different signaling pathways represents a novel mechanism that Rel/nuclear factor κB can repress the transcription of IFN-regulated genes in a cell type–specific manner.