Skin delivery of antioxidant surfactants based on gallic acid and hydroxytyrosol
Skin delivery of antioxidant surfactants based on gallic acid and hydroxytyrosol
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DOI：
10.1111/jphp.12382
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发表时间：
2015-07-01
影响因子：
3.3
通讯作者：
Luis Parra, Jose
中科院分区：
文献类型：
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作者：
Alonso, Cristina;Lucas, Ricardo;Luis Parra, Jose
目的本研究的目的是研究抗氧化化合物没食子酸和羟基酪醇及其衍生物己酸酯（没食子酸己酯和羟基酪醇己酸酯）和辛酸酯（没食子酸辛酯和辛酸酯衍生物）烷基酯（抗氧化表面活性剂）的皮肤吸收特性。在此之前，这些化合物的清除能力，表示为有效剂量ED 50，也determined.MethodsThe这些化合物的经皮吸收，获得了在体外的方法，使用猪皮肤活检Franz静态扩散细胞。化合物的抗自由基活性测定使用的1，1-二苯基-2-苦肼基自由基method.Key findingsThe经皮渗透的结果显示存在的抗氧化剂在皮肤的所有层。对于抗氧化剂表面活性剂（酯衍生物），吸收的化合物的含量更高。这种特殊的行为可能是由于更高的疏水性，这些化合物和存在的表面活性的抗氧化surfactors.ConclusionsThese新的抗氧化表面活性剂显示最佳性能，这可能是有用的乳化系统在化妆品和药物制剂的制备，因为它们合适的表面活性，因为它们可以保护皮肤免受氧化损伤。
ObjectivesThe aim of this study has been to investigate the dermal absorption profile of the antioxidant compounds gallic acid and hydroxytyrosol as well as their derivatives, hexanoate (hexyl gallate and hydroxytyrosol hexanoate) and octanoate (octyl gallate and octanoate derivative) alkyl esters (antioxidant surfactants). Previously, the scavenging capacity of these compounds, expressed as efficient dose ED50, has also determined.MethodsThe percutaneous absorption of these compounds was obtained by an in vitro methodology using porcine skin biopsies on Franz static diffusion cells. The antiradical activity of compounds was determined using the 1,1-diphenyl-2-picrylhydrazyl free radical method.Key findingsThe percutaneous penetration results show the presence of antioxidants in all layers of the skin. The content of the cutaneously absorbed compound is higher for the antioxidant surfactants (ester derivatives). This particular behaviour could be due to the higher hydrophobicity of these compounds and the presence of surface activity in the antioxidant surfactants.ConclusionsThese new antioxidant surfactants display optimum properties, which may be useful in the preparation of emulsified systems in cosmetic and pharmaceutical formulations because of their suitable surface activity and because they can protect the skin from oxidative damage.