Parasite manipulation of the proximate mechanisms that mediate social behavior in vertebrates
Parasite manipulation of the proximate mechanisms that mediate social behavior in vertebrates
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DOI：
10.1016/s0031-9384(03)00163-x
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发表时间：
2003-08-01
影响因子：
2.9
通讯作者：
Klein, SL
中科院分区：
文献类型：
--
作者：
Klein, SL
保罗·麦克莱恩在建立脊椎动物中调节社会行为表达的大脑区域方面发挥了重要作用。病原体可以利用这些核心机制来改变宿主的社会行为，包括攻击性、生殖性和亲代行为。尽管感染后的一些行为变化是由宿主介导的（例如，疾病行为），但其他行为改变是由病原体介导的，以促进传播。本综述的目的是提供寄生虫介导的社会行为变化的例子，并说明寄生虫通过感染神经元、引起中枢神经系统 (CNS) 炎症以及改变神经递质和激素通讯来影响宿主行为。其次，将使用比较方法来证明寄生虫对社会行为的影响在几类脊椎动物中保留下来，可能是因为寄生虫影响边缘系统和相关神经化学系统的系统发育原始结构。 (C) 2003 Elsevier Inc. 保留所有权利。
Paul MacLean was instrumental in establishing the brain regions that mediate the expression of social behaviors in vertebrates. Pathogens can exploit these central mechanisms to alter host social behaviors, including aggressive, reproductive, and parental behaviors. Although some behavioral changes after infection are mediated by the host (e.g., sickness behaviors), other behavioral modifications are mediated by the pathogen to facilitate transmission. The goal of this review is to provide examples of parasite-mediated changes in social behavior and to illustrate that parasites affect host behavior by infecting neurons, causing central nervous system (CNS) inflammation, and altering neurotransmitter and hormonal communication. Secondarily, a comparative approach will be used to demonstrate that the effects of parasites on social behavior are retained across several classes of vertebrates possibly because parasites affect the phylogenetically primitive structures of the limbic system and related neurochemical systems. (C) 2003 Elsevier Inc. All rights reserved.