ORGANIZER-SPECIFIC HOMEOBOX GENES IN XENOPUS-LAEVIS EMBRYOS
ORGANIZER-SPECIFIC HOMEOBOX GENES IN XENOPUS-LAEVIS EMBRYOS
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DOI：
10.1126/science.1677215
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发表时间：
1991-07-12
期刊：
影响因子：
56.9
通讯作者：
CHO, KWY
中科院分区：
文献类型：
--
作者：
BLUMBERG, B;WRIGHT, CVE;CHO, KWY
当移植到另一个胚胎时，早期非洲爪蟾原肠胚的背侧囊胚唇可以组织一个完整的次级体轴。寻找潜在的基因调控成分，特别是在组织者进行了鉴定，导致四种类型的互补DNA的同源框含有基因，满足这一标准。其中最丰富的编码的DNA结合特异性类似的果蝇前形态bicoid。其他三个也是同源的发育显着的果蝇基因。这四个基因可能参与了组织者发育潜能的调控。
The dorsal blastopore lip of the early Xenopus laevis gastrula can organize a complete secondary body axis when transplanted to another embryo. A search for potential gene regulatory components specifically expressed in the organizer was undertaken that resulted in the identification of four types of complementary DNAs from homeobox-containing genes that fulfill this criterion. The most abundant of these encodes a DNA-binding specificity similar to that of the Drosophila melanogaster anterior morphogen bicoid. The other three are also homologous to developmentally significant Drosophila genes. These four genes may participate in the regulation of the developmental potential of the organizer.