Perpetual expression of PAMPs necessary for optimal immune control and clearance of a persistent pathogen
Perpetual expression of PAMPs necessary for optimal immune control and clearance of a persistent pathogen
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DOI：
10.1038/ncomms3616
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发表时间：
2013-10-01
影响因子：
16.6
通讯作者：
Tarleton, Rick L.
中科院分区：
文献类型：
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作者：
Kurup, Samarchith P.;Tarleton, Rick L.
病原体相关分子模式（PAMPs）被认为是激发免疫反应的基础，但它们在影响这些反应中的作用超出了它们的启动还不太清楚。在这里，使用原生动物寄生虫克氏锥虫，这是缺乏强大的PAMPs，我们证明了PAMPs的连续表达的最佳抗病原体免疫的要求。虽然外源性PAMPs的共表达、暂时锚定和转基因表达都能增强早期适应性免疫应答，但只有转基因T. cruzi维持这些反应，导致增强的病原体清除。这些发现表明，PAMPs的功能，以加强适应性免疫反应远远超出其启动，并可能决定控制病原体的效率能够长期持久。
Pathogen-associated molecular patterns (PAMPs) are known to be fundamental in instigating immune responses, but their role in influencing these responses beyond their initiation is less well understood. Here, using the protozoan parasite Trypanosoma cruzi, which is deficient in strong PAMPs, we demonstrate a requirement for the continuous expression of PAMPs for optimal anti-pathogen immunity. Although co-inoculating with, temporary anchoring of and transgenic expression of exogenous PAMPs all result in enhanced early adaptive immune responses, only the continuous expression of bacterial PAMPs on transgenic T. cruzi sustains these responses, resulting in enhanced pathogen clearance. These findings demonstrate that PAMPs function to potentiate adaptive immune responses well beyond their initiation and may determine the efficiency of control of pathogens capable of long-term persistence.