LEARNING IMPAIRMENT FOLLOWING LESION OF THE BASAL NUCLEUS OF MEYNERT IN THE MARMOSET - MODIFICATION BY CHOLINERGIC DRUGS
LEARNING IMPAIRMENT FOLLOWING LESION OF THE BASAL NUCLEUS OF MEYNERT IN THE MARMOSET - MODIFICATION BY CHOLINERGIC DRUGS
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DOI：
10.1016/0006-8993(86)90904-2
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发表时间：
1986-06-18
期刊：
影响因子：
2.9
通讯作者：
BAKER, HF
中科院分区：
文献类型：
--
作者：
RIDLEY, RM;MURRAY, TK;BAKER, HF
5只常见绒猴(Callithrix Jacchus)单侧Meynert基底核(NBM)鹅掌酸损毁。7天后，额叶和颞叶新皮质的胆碱乙酰转移酶活性显著降低50%，杏仁核和apprx的胆碱乙酰转移酶活性显著降低40%。30%位于同侧大脑半球的运动、顶叶和枕叶皮质。与手术对照组相比，四只接受等量双侧鹅掌酸损毁的绒猴在新的视觉对象辨别学习和手术前学习的对象辨别的重新学习上受到严重损害。I.M.显著改善了受损动物的新学习能力。给予胆碱能激动剂槟榔碱。受损害的动物的学习能力随着时间的推移而提高，但这些动物对东莨菪碱对辨别学习的干扰作用具有不同的敏感性。这些结果表明，破坏上升的胆碱能通路的NBM损害损害了学习能力，但这种能力可以通过给予胆碱能激动剂基本上恢复。
Five common marmosets (Callithrix jacchus) received unilateral ibotenic acid lesions of the basal nucleus of Meynert (nBM). Seven days later, choline acetyltransferase activity was significantly reduced by 50% in the frontal and temporal neocortex, 40% in the amygdala, and .apprx. 30% in the motor, parietal and occipital cortex in the ipsilateral hemisphere. Four marmosets receiving equivalent bilateral ibotenic acid lesions were severely impaired on new visual object discrimination learning and on relearning an object discrimination learned prior to surgery when compared with operated controls. New learning in lesioned animals was substantially improved by i.m. administration of the cholinergic agonist arecoline. Lesioned animals learning ability improved with time but these animals were then differentially sensitive to the disruptive effect of scopolamine on discrimination learning. These results show that lesions of the nBM which destroy the rising cholinergic pathways impair learning ability but that this ability can be substantially restored by administration of a cholinergic agonist.