Regional cerebral blood flow in the amygdala and medial prefrontal cortex during traumatic imagery in male and female Vietnam veterans with PTSD
Regional cerebral blood flow in the amygdala and medial prefrontal cortex during traumatic imagery in male and female Vietnam veterans with PTSD
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DOI：
10.1001/archpsyc.61.2.168
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发表时间：
2004-02-01
影响因子：
--
通讯作者：
Pitman, RK
中科院分区：
文献类型：
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作者：
Shin, LM;Orr, SP;Pitman, RK
内容：创伤后应激障碍（PTSD）的理论神经解剖模型和以往的PTSD神经影像学研究的结果突出了杏仁核和内侧前额叶区域在这种疾病中的潜在重要性。然而，这些大脑区域之间的功能关系在PTSD.Objective：研究杏仁核和内侧前额叶区域之间的关系，在症状激发在男性战斗退伍军人（MCVs）和女性护士退伍军人（FNVs）与PTSD.Design：病例对照研究。事件心理生理和情绪的自我报告数据也被获得，以确认脚本驱动的图像的预期效果。（7男10女）患有创伤后应激障碍的越战老兵（PTSD组）和19（9男10女）无创伤后应激障碍的越战老兵主要观察指标：我们使用正电子发射断层扫描和脚本驱动的图像范式来研究在回忆个人创伤和中性记忆过程中的局部脑血流量（rCBF）。在创伤性与中性比较中，PTSD组额内侧回的rCBF降低。当按亚组分别进行比较时，患有PTSD的MCV和FNV表现出这些内侧额回减少。只有MCV表现出左杏仁核的rCBF增加。然而，对于PTSD的两个亚组，额内侧回的rCBF变化与左杏仁核和右杏仁核/杏仁周围核的rCBF变化呈负相关。皮层此外，在创伤性条件下，两个亚组与PTSD，症状的严重程度呈正相关，右杏仁核的rCBF和负相关的rCBF在内侧额gyrus.Conclusions：这些结果表明，内侧前额叶皮层和杏仁核的功能在PTSD和反对活动之间的相互关系，这些地区和症状的严重程度与目前的功能神经解剖模型，这种疾病。
Context: Theoretical neuroanatomic models of posttraumatic stress disorder (PTSD) and the results of previous neuroimaging studies of PTSD highlight the potential importance of the amygdala and medial prefrontal regions in this disorder. However, the functional relationship between these brain regions in PTSD has not been directly examined.Objective: To examine the relationship between the amygdala and medial prefrontal regions during symptom provocation in male combat veterans (MCVs) and female nurse veterans (FNVs) with PTSD.Design: Case-control study.Setting: Academic medical center. events. Psychophysiologic and emotional self-report data also were obtained to confirm the intended effects of script-driven imagery.Participants: Volunteer sample of 17 (7 men and 10 women) Vietnam veterans with PTSD (PTSD group) and 19 (9 men and 10 women) Vietnam veterans without PTSD (control group).Main Outcome Measures: We used positron emission tomography and the script-driven imagery paradigm to study regional cerebral blood flow (rCBF) during the recollection of personal traumatic and neutralResults: The PTSD group exhibited rCBF decreases in medial frontal gyrus in the traumatic vs neutral comparison. When this comparison was conducted separately by subgroup, MCVs and FNVs with PTSD exhibited these medial frontal gyrus decreases. Only MCVs exhibited rCBF increases in the left amygdala. However, for both subgroups with PTSD, rCBF changes in medial frontal gyrus were inversely correlated with rCBF changes in the left amygdala and the right amygdala/periamygdaloid. cortex. Furthermore, in the traumatic condition, for both subgroups with PTSD, symptom severity was positively related to rCBF in the right amygdala and negatively related to rCBF in medial frontal gyrus.Conclusions: These results suggest a reciprocal relationship between medial prefrontal cortex and amygdala function in PTSD and opposing associations between activity in these regions and symptom severity consistent with current functional neuroanatomic models of this disorder.