Variable Eating Patterns: A Potential Novel Risk Factor for Systemic Inflammation in Women.
Variable Eating Patterns: A Potential Novel Risk Factor for Systemic Inflammation in Women.
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多样化的饮食模式：女性全身炎症的潜在新危险因素。
DOI：
10.1093/abm/kaac042
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Aggarwal,Brooke
中科院分区：
文献类型：
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作者：
Makarem,Nour;Zuraikat,FarisM;Caceres,Billy;Sears,DorothyD;St-Onge,Marie-Pierre;Lai,Yue;Aggarwal,Brooke
背景饮食模式的时间和规律可能在全身炎症中起作用，因为负责炎症信号日常节律的生物钟受到食物摄入的影响。目的评估每周内和工作日-周末进食模式的差异与高敏C反应蛋白(HsCRP)的关系。方法来自美国心脏协会战略重点研究网络的103名美国女性社区样本完成了一份进餐时间调查问卷，并提供了用于测量hsCRP的血样。工作日和周末进食开始时间、进食结束时间和夜间禁食持续时间的差异被计算为进食时差指标。进食时间模式的周内变异性由这些变量的标准差(SD)定义。结果工作日-周末进食结束时间每增加30分钟与hsCRP升高13%相关(p=0.023)。同样，进食结束时间SD每增加30分钟，反映出最后一次进餐时间的变异性更大，hsCRP就会高出29%。每1小时的工作日-周末夜间禁食时间差，hsCRP升高45%(p=0.003)。夜间禁食持续时间SD每增加30分钟，代表着每日禁食/进食时间跨度的变异性越大，hsCRP.升高46%。结论不同的进食时间模式与hsCRP升高有关。需要进行干预研究，以确定稳定就餐时间是否代表了一种减少慢性炎症的新策略。
BackgroundThe timing and regularity of eating patterns could play a role in systemic inflammation, as circadian clocks responsible for daily rhythms of inflammatory signaling are entrained by food intake.PurposeTo evaluate associations of intra-weekly and weekday-weekend differences in eating timing patterns with high-sensitivity C-reactive protein (hsCRP).MethodsA community-based sample of 103 U.S. women from the American Heart Association Go Red for Women Strategically Focused Research Network completed a meal-timing questionnaire and provided a blood sample for measurement of hsCRP. Differences in weekday versus weekend eating start time, eating end time, and nightly fasting duration were calculated as eating jetlag metrics. Intra-weekly variability in eating timing patterns was defined by the standard deviation (SD) of these variables. Multivariable linear regression models were used to evaluate cross-sectional associations of eating timing variability metrics with hsCRP.ResultsEach additional 30-min difference in weekday–weekend eating end time was related to 13% higher hsCRP (p= .023). Similarly, every 30-min increase in eating end timeSD, reflecting greater variability in timing of last eating occasion, was associated with 29% higher hsCRP. Per 1-hr weekday–weekend difference in nightly fasting duration, there was a 45% elevation in hsCRP (p= .003). Every 30-min increase in nightly fasting duration SD, representing greater variability in span of the daily fasting/eating periods, was associated with 46% higher hsCRP.ConclusionsVariable eating timing patterns were associated with higher hsCRP. Intervention studies are needed to determine whether stabilizing the timing of eating occasions may represent a novel strategy to reduce chronic inflammation.