Cumulus-oocyte complex interactions during oocyte maturation.
Cumulus-oocyte complex interactions during oocyte maturation.
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DOI：
10.1016/s0074-7696(04)35006-0
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
M. Yokoo;E. Sato
中科院分区：
文献类型：
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作者：
M. Yokoo;E. Sato
在大多数哺乳动物中，卵泡中的卵母细胞被紧密堆积的积云细胞层包围，形成积云-卵母细胞复合体。在排卵期，积云细胞由致密的细胞团变为分散的细胞结构，并合成和沉积粘液样细胞间基质，这一过程称为积云扩张。积云的扩张被认为影响卵母细胞成熟过程中的各种基本发育变化。至少在猪体内，卵丘-卵母细胞复合体的体积膨胀与卵母细胞成熟、受精和胚胎发育的结果相关。因此，需要对卵积云扩张的详细功能研究来阐明卵母细胞成熟的机制。我们总结了目前关于(1)卵丘-卵母细胞复合物在卵母细胞成熟过程中的形态变化，(2)诱导卵丘扩张的卵泡因子，(3)卵丘扩张在卵母细胞成熟中的作用，(4)卵母细胞成熟的细胞质调节因子，以及(5)卵丘扩张的可能作用。
In most mammals, the oocyte in the Graafian follicle is surrounded by tightly packed layers of cumulus cells, forming the cumulus-oocyte complex. During the preovulatory period, cumulus cells change from a compact cell mass into a dispersed structure of cells for the synthesis and deposition of a mucoid intercellular matrix, a process referred to as cumulus expansion. Cumulus expansion is thought to influence a variety of fundamental developmental changes during oocyte maturation. Volumetric expansion of the cumulus-oocyte complex correlates, at least in pig, with the outcome of oocyte maturation, fertilization, and embryo development. Therefore, detailed functional studies of cumulus expansion seem to be required to elucidate the mechanism of oocyte maturation. We summarize the current knowledge about (1) morphological changes of cumulus-oocyte complexes during oocyte maturation,(2) follicle factors inducing cumulus expansion,(3) the role of cumulus expansion in oocyte maturation,(4) cytoplasmic regulators of oocyte maturation, and (5) possible roles of cumulus expansion.