ASSOCIATION AND ACTIVATION OF JAK-TYK KINASES BY CNTF-LIF-OSM-IL-6 BETA-RECEPTOR COMPONENTS
ASSOCIATION AND ACTIVATION OF JAK-TYK KINASES BY CNTF-LIF-OSM-IL-6 BETA-RECEPTOR COMPONENTS
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DOI：
10.1126/science.8272873
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发表时间：
1994-01-07
期刊：
影响因子：
56.9
通讯作者：
YANCOPOULOS, GD
中科院分区：
文献类型：
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作者：
STAHL, N;BOULTON, TG;YANCOPOULOS, GD
最近定义的细胞因子家族，包括睫状神经营养因子（CNTF）、白血病抑制因子（LIF）、制瘤素M（OSM）和白细胞介素-6（IL-6），利用细胞质酪氨酸激酶的Jak-Tyk家族。该细胞因子家族的β受体组分gp 130和LIF受体β与Jak-Tyk激酶组成性相关。这些激酶的激活是受体β组分的配体诱导二聚化的结果。与迄今为止研究的其他细胞因子受体不同，CNTF细胞因子家族的受体利用Jak-Tyk家族的所有已知成员，但在不同细胞系中诱导不同的Jak-Tyk磷酸化模式。
A recently defined family of cytokines, consisting of ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), and interleukin-6 (IL-6), utilize the Jak-Tyk family of cytoplasmic tyrosine kinases. The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. Activation of these kinases occurs as a result of ligand-induced dimerization of the receptor beta components. Unlike other cytokine receptors studied to date, the receptors for the CNTF cytokine family utilize all known members of the Jak-Tyk family, but induce distinct patterns of Jak-Tyk phosphorylation in different cell lines.