Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics.
Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics.
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DOI：
10.3389/fbioe.2021.622524
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发表时间：
2021
影响因子：
5.7
通讯作者：
Barone DG
中科院分区：
文献类型：
--
作者：
Carnicer-Lombarte A;Chen ST;Malliaras GG;Barone DG
任何异物植入体内都会导致炎症和纤维化过程--异物反应(FBR)。一旦植入组织，免疫系统的细胞就会被异物吸引，并试图将其降解。如果这种降解失败，成纤维细胞就会包裹这种材料，形成一种物理屏障，将其与身体的其他部分隔离开来。医疗器械的长期植入面临着FBR带来的巨大挑战，因为细胞反应破坏了植入物与其靶组织之间的界面。对于神经假体植入物来说尤其如此--神经假体植入物是一种植入神经的装置，用于治疗感觉丧失、肌肉瘫痪、慢性疼痛和癫痫等疾病。神经假体依靠神经组织和电极之间的紧密连接来检测轴突携带的微小电信号，和/或电刺激神经内的轴突小亚群。此外，随着微制造技术的进步推动神经植入物越来越小型化，对稳定、亲密的植入物-组织界面的需求很可能很快成为新的神经假体植入物技术发展的限制因素。在这里，我们提供了导致快堆发展的材料-细胞相互作用的概述。我们回顾了目前的神经修复技术(袖套、穿透和再生界面)，以及这些技术的长期功能如何受到FBR的限制。最后，我们讨论了如何利用材料特性(如硬度和大小)、药物治疗或可生物降解材料的使用来最大限度地减少神经假体的FBR，并提高其长期稳定性。
The implantation of any foreign material into the body leads to the development of an inflammatory and fibrotic process—the foreign body reaction (FBR). Upon implantation into a tissue, cells of the immune system become attracted to the foreign material and attempt to degrade it. If this degradation fails, fibroblasts envelop the material and form a physical barrier to isolate it from the rest of the body. Long-term implantation of medical devices faces a great challenge presented by FBR, as the cellular response disrupts the interface between implant and its target tissue. This is particularly true for nerve neuroprosthetic implants—devices implanted into nerves to address conditions such as sensory loss, muscle paralysis, chronic pain, and epilepsy. Nerve neuroprosthetics rely on tight interfacing between nerve tissue and electrodes to detect the tiny electrical signals carried by axons, and/or electrically stimulate small subsets of axons within a nerve. Moreover, as advances in microfabrication drive the field to increasingly miniaturized nerve implants, the need for a stable, intimate implant-tissue interface is likely to quickly become a limiting factor for the development of new neuroprosthetic implant technologies. Here, we provide an overview of the material-cell interactions leading to the development of FBR. We review current nerve neuroprosthetic technologies (cuff, penetrating, and regenerative interfaces) and how long-term function of these is limited by FBR. Finally, we discuss how material properties (such as stiffness and size), pharmacological therapies, or use of biodegradable materials may be exploited to minimize FBR to nerve neuroprosthetic implants and improve their long-term stability.
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影响因子：
4
作者：
Barrese JC;Aceros J;Donoghue JP
通讯作者：
Donoghue JP
影响因子：
5.1
作者：
Ben-Menachem E;Revesz D;Simon BJ;Silberstein S
通讯作者：
Silberstein S
DOI：
10.1038/sc.1982.65
发表时间：
1982-01-01
期刊：
PARAPLEGIA
影响因子：
--
作者：
BRINDLEY, GS;POLKEY, CE;RUSHTON, DN
通讯作者：
RUSHTON, DN
影响因子：
3.5
作者：
Burridge, Jane;Haugland, Morten;Sinkjaer, Thomas
通讯作者：
Sinkjaer, Thomas
影响因子：
5.1
作者：
Christie, Breanne P.;Freeberg, Max;Triolo, Ronald J.
通讯作者：
Triolo, Ronald J.