Cellular senescence, ageing and disease
Cellular senescence, ageing and disease
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DOI：
10.1007/s11357-008-9075-y
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发表时间：
2009-03-01
期刊：
影响因子：
--
通讯作者：
Burton, D. G. A.
中科院分区：
文献类型：
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作者：
Burton, D. G. A.
细胞衰老是单个有丝分裂细胞的不可逆生长停滞，其结果显示出根本改变的表型，这被认为会损害组织功能并使组织在逐渐积累时易于发生疾病和/或进展。然而，在过去，对衰老机制的研究通常与疾病发展分开研究和治疗。这可能部分是由于缺乏对衰老机制的了解，以及难以将已知的知识应用于疾病发展模型。只有在过去的10年里，随着对衰老表型的了解和检测人体组织中衰老细胞的能力的增加，生物学家才能够研究细胞衰老与疾病之间的关系。因此，这篇综述汇集并讨论了最近的发现，这些发现表明细胞衰老确实有助于衰老和疾病的发展/进展。
Cellular senescence is the irreversible growth arrest of individual mitotic cells, which as a consequence display a radically altered phenotype that is thought to impair tissue function and predispose tissues to disease development and/or progression as they gradually accumulate. However, in the past, research into mechanisms of ageing has commonly been researched and treated separately from disease development. This may partly be due to the lack of understanding concerning mechanisms of ageing and the difficulty in implementing what was known into models of disease development. Only in the last 10 years, with increasing knowledge of the senescent phenotype and the ability to detect senescent cells in human tissues, have biologists been able to investigate the relationship between cellular senescence and disease. This review therefore brings together and discusses recent findings which suggest that cellular senescence does contribute to ageing and the development/progression of disease.