A novel bioactivity of omega-3 polyunsaturated fatty acids and their ester derivatives
A novel bioactivity of omega-3 polyunsaturated fatty acids and their ester derivatives
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DOI：
10.1111/j.2041-1014.2009.00553.x
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发表时间：
2010-02-01
影响因子：
3.7
通讯作者：
Ebersole, J. L.
中科院分区：
文献类型：
--
作者：
Huang, C. B.;Ebersole, J. L.
富含omega-3多不饱和脂肪酸(n-3 PUFA)的鱼油被广泛用作饮食或营养补充剂，具有许多好处，包括作为一种抗炎药物，尤其与动脉粥样硬化有关。虽然n-3多不饱和脂肪酸被认为能够通过升高血清和细胞膜中这些脂肪酸的含量来减少炎症，从而改善口腔健康，但对于这些脂肪酸可能直接影响触发慢性炎症反应的口腔细菌的生存和生长的可能性缺乏信息。分析了n-3脂肪酸二十碳五烯酸(EPA)、二十二碳六烯酸(DHA)和α-亚麻酸(ALA)及其脂肪酸乙酯、ALAEE、EPAEE、DHAEE对口腔致病菌的抑菌活性。本研究展示了三种主要的n-3多不饱和脂肪酸、EPA、DHA和ALA及其酯类化合物的新生物活性。实验数据表明，n-3多不饱和脂肪酸及其酯类化合物对多种口腔病原菌具有较强的抗菌活性，包括变形链球菌、白色念珠菌、伴生放线杆菌、核梭杆菌和牙龈卟啉单胞菌。本研究提示，n-3多不饱和脂肪酸除了具有抗炎作用外，还可能通过其抗菌活性对改善口腔健康起到积极的治疗作用。
Fish oil, enriched in omega-3 polyunsaturated fatty acids (n-3 PUFA), is widely used as a dietary or nutritional supplement with numerous benefits, including as an anti-inflammatory particularly linked to atherosclerosis. While n-3 PUFA have been suggested to be able to improve oral health through a reduction in inflammation through elevations in these fatty acids in serum and cellular membranes, information is lacking for the possibility that these fatty acids could directly impact the survival and growth of the oral bacteria that trigger the chronic inflammatory responses. The n-3 fatty acids, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and a-linolenic acid (ALA), and their fatty acid ethyl esters, ALAEE, EPAEE, DHAEE were analysed for antibacterial activity against oral pathogens. This study demonstrated a novel bioactivity of the three major n-3 PUFA, EPA, DHA, and ALA, and their ester derivatives. Our experimental data indicated that n-3 PUFA and their ester derivatives exhibited strong antibacterial activity against various oral pathogens, including Streptococcus mutans, Candida albicans, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, and Porphyromonas gingivalis. This study suggested that n-3 PUFA could have a positive therapeutic effect for improving oral health via their antibacterial activities, besides their anti-inflammatory effects.