Neurotrophic keratitis
Neurotrophic keratitis
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DOI：
10.1038/sj.eye.6700616
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发表时间：
2003-11-01
期刊：
影响因子：
3.9
通讯作者：
Lambiase, A
中科院分区：
文献类型：
--
作者：
Bonini, S;Rama, P;Lambiase, A
神经营养性角膜病变是由三叉神经损伤引起的一种退行性角膜疾病。角膜感觉神经丧失的损害是导致角膜上皮缺陷、溃疡和穿孔的原因。在本报告中，我们回顾了该病的发病机制、诊断和治疗方面。准确的病史和临床检查，包括脑神经功能，以及眼表的临床特征是及时诊断的关键。评估角膜敏感度和泪膜功能也是重要的诊断步骤。根据疾病的临床分期进行特定的内科和外科治疗，往往能够阻止其进展。展望了神经肽和生长因子在医学治疗中的应用前景。
Neurotrophic keratopathy is a degenerative corneal disease induced by an impairment of trigeminal nerve. Impairment of loss of corneal sensory innervation is responsible for corneal epithelial defects, ulcer, and perforation. In the present report, we reviewed the pathogenesis, diagnosis, and therapeutic aspects of this disease. An accurate history and clinical examination, including the function of cranial nerves, together with the clinical features of the ocular surface are essential for a prompt diagnosis. The evaluation of the corneal sensitivity and tear film function are important diagnostic steps as well. Specific medical and surgical treatments, based on the clinical staging of the disease, are often able to halt its progression. Future developments in the medical treatment including the administration of neuropeptide and growth factors are presented.