Genetic relationship in southern African Crimean-Congo haemorrhagic fever virus isolates: evidence for occurrence of reassortment
Genetic relationship in southern African Crimean-Congo haemorrhagic fever virus isolates: evidence for occurrence of reassortment
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DOI：
10.1017/s0950268808001878
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发表时间：
2009-09-01
影响因子：
4.2
通讯作者：
Swanepoel, R.
中科院分区：
文献类型：
--
作者：
Burt, F. J.;Paweska, J. T.;Swanepoel, R.
克里米亚-刚果出血热（CCHF）是一种广泛分布于非洲、亚洲和东欧的蜱传病毒性人畜共患病。CCHF基因组区段的重配已显示在自然界中发生。因此，我们调查了南部非洲分离株的遗传关系，每个RNA片段，S，M和L的部分序列数据，并比较使用邻居加入方法构建的树拓扑结构。共研究了21个南部非洲分离株。在S、M和L序列数据集中发现的不一致性涉及组转换，意味着15个分离株的重配。感染的分离株明显地从一个通常发现主要是亚洲株的群体中获得M节段，这表明重配可能影响病毒的致病性。
Crimean-Congo haemorrhagic fever (CCHF) is a tick-borne viral zoonosis widely distributed in Africa, Asia and eastern Europe. Reassortment of CCHF genome segments has been shown to occur in nature. We therefore investigated the genetic relationship of southern African isolates using partial sequence data for each RNA segment, S, M and L, and comparing the tree topologies constructed using a neighbour joining method. A total of 21 southern African isolates were studied. The incongruencies which were identified in S, M and L sequence datasets involved group switching implying reassortment for 15 isolates. A higher fatality rate occurred in patients infected with isolates which had apparently acquired M segments from a group in which predominantly Asian strains are usually found. This suggests that reassortment may affect the pathogenicity of the virus.