COMPARATIVE STUDIES ON THE EFFECTS OF LA SOTA AND KOMAROV VACCINE ANTIBODIES ON ORGAN DISTRIBUTION , PERSISTENCE AND SHEDDING OF KUDU 113 VIRUS IN CHICKENS
COMPARATIVE STUDIES ON THE EFFECTS OF LA SOTA AND KOMAROV VACCINE ANTIBODIES ON ORGAN DISTRIBUTION , PERSISTENCE AND SHEDDING OF KUDU 113 VIRUS IN CHICKENS
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LA SOTA 和 KOMAROV 疫苗抗体对鸡 kudu 113 病毒器官分布、持久性和排毒影响的比较研究
DOI：
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发表时间：
2016
期刊：
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通讯作者：
J. Okoye
中科院分区：
文献类型：
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作者：
E. C. Okwor;D. Eze;G. Echeonwu;J. Ibu;P. Eze;J. Okoye
从慢生和中生菌株衍生的疫苗用于保护鸡的临床新城疫。在尼日利亚，没有关于这些疫苗对病毒复制和脱落提供保护的信息。本研究比较了La Sota和Komarov疫苗在库度113病毒攻毒鸡体内保护鸡免受复制和脱落的能力。将550只日龄雏鸡分为4组；未接种且未攻毒（G1）、未接种且攻毒（G2）、La Sota接种且攻毒（G3）、Komarov接种且攻毒（G4）。取G2、G3和G4批次的雏鸟，按规定的时间间隔用Kudu 113攻毒。评估了病毒在受感染禽鸟器官中的分布和持久性以及在其粪便中的脱落情况。这两种疫苗都不能阻止病毒的复制和脱落，但显著减少了Kudu 113的分布和脱落。与La Sota相比，Komarov疫苗显示出更高的病毒复制和脱落的减少。两例病例的峰值分布和脱落均出现在妊娠第4天至第7天，病毒在感染鸡的粪便中最多持续14天，在妊娠第4天和妊娠第3天分别持续21天。
Vaccines derived from the lentogenic and mesogenic strains are used for the protection of clinical ND in chickens. No information is available on the protection offered by these vaccines against virus replication and shedding in Nigeria. This study compared the abilities of La Sota and Komarov vaccines to protect chickens against replication and shedding in chickens challenged with the velogenic Kudu 113 virus. Five hundred and fifty day old chicks were assigned into four groups; unvaccinated and unchallenged (G1), unvaccinated and challenged (G2) La Sota vaccinated and challenged (G3) and Komarov vaccinated and challenged (G4). Batches of birds in G2, G3 and G4 were taken at specified intervals for challenge with Kudu 113. Virus distribution and persistence in organs and shedding in the faeces of the infected birds were assessed. Both vaccines did not prevent viral replication and shedding but significantly reduced the distribution and shedding of Kudu 113. Komarov vaccine showed higher reduction of viral replication and shedding when compared with La Sota. Peak distribution and shedding in both cases were seen between days 4 and 7 PC and virus persisted in the faeces of infected chickens for a maximum of 14 days in G4 and 21 days in G3.