Chronic toxicity of 3,4,3',4'- and 2,5,2',5'-tetrachlorobiphenyls in rhesus macaques.
Chronic toxicity of 3,4,3',4'- and 2,5,2',5'-tetrachlorobiphenyls in rhesus macaques.
复制标题
3,4,3,4- 和 2,5,2,5-四氯联苯对恒河猴的慢性毒性。
DOI：
10.1016/0041-008x(80)90288-4
复制
发表时间：
1980
影响因子：
3.8
通讯作者：
H. Cory
中科院分区：
文献类型：
--
作者：
W. McNulty;G. Becker;H. Cory
含0.3 - 3.0 ppm 3，4，3 ′，4 ′-四氯联苯的饲料在1 - 6个月内导致恒河猴氯痤疮、体重减轻和死亡。尸检中观察到的病变与商用多氯联苯（Aroclors 1242和1248）中毒后报告的病变相同，即鳞状上皮化生和皮脂腺萎缩、甲床角化过度、胸腺退化和胃粘膜粘液增生。在相同的饮食水平下，2，5，2 ′，5 ′-四氯联苯对猴子没有临床影响或病理损害。这些研究结果与多氯联苯的毒性与苯环邻位氯化程度呈负相关的假设一致。
A diet containing 0.3 to 3.0 ppm 3,4,3′,4′-tetrachlorobiphenyl caused chloracne, weight loss, and death in rhesus monkeys in 1 to 6 months. The lesions seen at autopsy were the same as those reported after poisoning with commercial polychlorinated biphenyls (Aroclors 1242 and 1248), namely, squamous metaplasia and atrophy of sebaceous glands, hyperkeratosis of the nail beds, involution of the thymus, and mucous hyperplasia of the gastric mucosa. No clinical effects or pathologic lesions were observed in monkeys fed 2,5,2′,5′-tetrachlorobiphenyl at the same dietary levels. These findings are consistent with the hypothesis that toxicity of polychlorinated biphenyls is inversely related to the degree of chlorination in the ortho positions of the phenyl rings.