Effects of azole antifungal drugs on the transition from yeast cells to hyphae in susceptible and resistant isolates of the pathogenic yeast Candida albicans
Effects of azole antifungal drugs on the transition from yeast cells to hyphae in susceptible and resistant isolates of the pathogenic yeast Candida albicans
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DOI：
10.1128/aac.43.4.763
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发表时间：
1999-04-01
影响因子：
4.9
通讯作者：
White, TC
中科院分区：
文献类型：
--
作者：
Ha, KC;White, TC
由白色念珠菌引起的口腔感染是人类免疫缺陷病毒感染患者中最常见和最早的机会性感染。唑类抗真菌药物的广泛使用导致了耐药性的发展，在治疗艾滋病患者和其他免疫功能低下个体的酵母菌感染方面造成了一个主要问题。已经确定了几种导致耐药性的分子机制。在白色念珠菌中，从酵母细胞（胚孢子）到丝状细胞（菌丝）形态转换的能力是一个重要的毒力因素，它有助于念珠菌在宿主组织中的传播，并促进感染和侵袭。抗真菌药物耐药性水平与在唑类药物存在下形成菌丝的能力之间存在正相关关系。在存在唑类药物的菌丝诱导条件下，耐药的临床分离株形成菌丝，而敏感的酵母菌分离株则不形成菌丝。这种相关性是在易感和耐药菌株群体的随机样本中观察到的，与耐药机制无关。s -35-蛋氨酸掺入表明生长抑制不足以解释菌丝形成的抑制，但它可能有助于这种抑制。
Oral infections caused by the yeast Candida albicans are some of the most frequent and earliest opportunistic infections in human immunodeficiency virus-infected patients. The widespread use of azole antifungal drugs has led to the development of drug resistance, creating a major problem in the treatment of yeast infections in AIDS patients and other immunocompromised individuals. Several molecular mechanisms that contribute to drug resistance have been identified. In C. albicans, the ability to morphologically switch from yeast cells (blastospores) to filamentous forms (hyphae) is an important virulence factor which contributes to the dissemination of Candida in host tissues and which promotes infection and invasion. A positive correlation between the level of antifungal drug resistance and the ability to form hyphae in the presence of azole drugs has been identified. Under hypha-inducing conditions in the presence of an azole drug, resistant clinical isolates form hyphae, while susceptible yeast isolates do not. This correlation is observed in a random sample from a population of susceptible and resistant isolates and is independent of the mechanisms of resistance. S-35-methionine incorporation suggests that growth inhibition is not sufficient to explain the inhibition of hyphal formation, but it may contribute to this inhibition.