Novel routes of opioid administration
Novel routes of opioid administration
复制标题
DOI：
10.1093/bja/81.1.3
复制
发表时间：
1998-07-01
影响因子：
9.8
通讯作者：
Rowbotham, DJ
中科院分区：
文献类型：
--
作者：
Alexander-Williams, JM;Rowbotham, DJ
在麻醉的早期，阿片类药物传统上是通过肌内和静脉途径给药，其他给药方法被认为是新的。然而，由于在过去几十年中对急性和慢性疼痛的兴趣不断扩大，麻醉师常规地通过口服、皮下、直肠、鞘内、硬膜外和经皮途径给予阿片类药物。所有这些交付方式现在都可以被视为常规方式，尽管在某些情况下产品许可证的发放难以预料。在这篇简短的综述中，我们将考虑三种仍然被认为是新颖的阿片类药物给药方法：鼻内和吸入给药以及离子电渗疗法。有些人可能认为关节内给药是一种新方法，但最近在其他地方对此进行了详细审查。20
In the early days of anaesthesia, opioids were traditionally given by the intramuscular and intravenous routes and other methods of administration were considered as novel. However, because of expanding interest in both acute and chronic pain over the past few decades, the anaesthetist routinely administers opioids via the oral, subcutaneous, rectal, intrathecal, extradural and transdermal routes. All these modes of delivery can now be considered as conventional, despite the vagaries of product licensing in some situations. In this short review, we shall consider three methods of opioid administration that can still be considered as novel: intranasal and inhalational administration and iontophoresis. Some may consider intra-articular administration as novel, but this has recently been reviewed in detail elsewhere. 20