Does comorbid Social Anxiety Disorder impact the clinical presentation of principal Major Depressive Disorder?
Does comorbid Social Anxiety Disorder impact the clinical presentation of principal Major Depressive Disorder?
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DOI：
10.1016/j.jad.2006.10.014
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发表时间：
2007-06-01
影响因子：
6.6
通讯作者：
Zimmerman, Mark
中科院分区：
文献类型：
--
作者：
Dalrymple, Kristy L.;Zimmerman, Mark
背景：虽然以前的研究已经研究了主性社交焦虑障碍(SAD)的共病，但很少有研究研究共病SAD患者寻求治疗的障碍。此外，研究表明抑郁障碍通常与SAD相关，但很少有人研究这种特殊情况下患者的临床特征。方法：本研究调查了577名确诊为SAD的患者中各种主轴I障碍的患病率。结果：与先前的研究一致，重度抑郁障碍(MDD)是合并SAD患者中最常见的主要诊断。比较两组患者的人口学特征和临床特征。与MDD患者相比，MDD-SAD患者在社会功能、抑郁发作持续时间、自杀意念、工作时间、当前是否存在酗酒/依赖以及MDD的发病年龄方面更为严重。社会功能、发病持续时间、自杀意念和MDD的发病年龄仍然显著，即使在控制了其他合并症之后。结论：研究结果表明，需要进一步的研究来确定如何对这种常见的合并症进行治疗。(C)2006爱思唯尔B.V.保留所有权利。
Background: Although previous research has examined comorbidity in principal Social Anxiety Disorder (SAD), few studies have examined the disorders for which those with comorbid SAD seek treatment. Further, studies have shown that depressive disorders often are associated with SAD, but few have examined the clinical characteristics of patients with this particular comorbidity.Method: The current study examined the prevalence of various principal Axis I disorders in 577 individuals diagnosed with comorbid SAD.Results: Consistent with previous research, Major Depressive Disorder (MDD) was the most frequent principal diagnosis in patients with comorbid SAD. Those with principal MDD and comorbid SAD (MDD-SAD) were compared to those with MDD without SAD (MDD) on demographic and clinical characteristics. Patients with MDD-SAD versus those with MDD were more severe in terms of social functioning, duration of depressive episode, suicidal ideation, time out of work, presence of current alcohol abuse/dependence, and age of onset of MDD. Social functioning, duration of episode, suicidal ideation, and age of onset of MDD remained significant even after controlling for additional comorbid disorders.Conclusions: Findings suggest the need for future research to determine how treatments could be adapted for this commonly occurring comorbidity. (C) 2006 Elsevier B.V. All rights reserved.