Cancer stem cells: a metastasizing menace!
Cancer stem cells: a metastasizing menace!
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癌症干细胞：转移威胁！
DOI：
10.1002/cam4.629
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发表时间：
2016-04
期刊：
影响因子：
4
通讯作者：
Bandhavkar S
中科院分区：
文献类型：
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作者：
Bandhavkar S
癌症是全世界死亡的主要原因之一，并且估计在未来5年内将是超过180亿人死亡的原因。癌症的诊断和治疗已经取得了进展;然而，对潜在细胞生物学的正确理解仍然是一个未解之谜。目前的治疗包括放射、手术和/或化疗的组合。然而，这些治疗并不是完全治愈，只是为了缩小肿瘤，在大多数情况下，肿瘤会复发。一些证据表明存在癌症干细胞（CSC）或肿瘤起始干细胞样细胞，肿瘤中存在的一小群细胞，能够自我更新并产生分化的后代。这些CSC的存在可以归因于癌症治疗的失败，因为这些细胞被认为表现出治疗抗性。因此，越来越多的关注已经给予CSC的研究，以解决与癌症有关的治疗问题。在这一领域的研究进展导致了新的策略来治疗几种恶性肿瘤的发展，并已成为讨论的热点。在这篇综述中，我们将简要地集中在肿瘤干细胞的主要特点，治疗意义，并在癌症治疗的前景。
Cancer is one of the leading causes of death worldwide, and is estimated to be a reason of death of more than 18 billion people in the coming 5 years. Progress has been made in diagnosis and treatment of cancer; however, a sound understanding of the underlying cell biology still remains an unsolved mystery. Current treatments include a combination of radiation, surgery, and/or chemotherapy. However, these treatments are not a complete cure, aimed simply at shrinking the tumor and in majority of cases, there is a relapse of tumor. Several evidences suggest the presence of cancer stem cells (CSCs) or tumor‐initiating stem‐like cells, a small population of cells present in the tumor, capable of self‐renewal and generation of differentiated progeny. The presence of these CSCs can be attributed to the failure of cancer treatments as these cells are believed to exhibit therapy resistance. As a result, increasing attention has been given to CSC research to resolve the therapeutic problems related to cancer. Progress in this field of research has led to the development of novel strategies to treat several malignancies and has become a hot topic of discussion. In this review, we will briefly focus on the main characteristics, therapeutic implications, and perspectives of CSCs in cancer therapy.