Telomere Length and Risk of Stroke in Chinese
Telomere Length and Risk of Stroke in Chinese
复制标题
中文端粒长度与中风风险
DOI：
10.1161/strokeaha.111.637207
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发表时间：
2012-03-01
期刊：
影响因子：
8.3
通讯作者：
Wang, Dao Wen
中科院分区：
文献类型：
--
作者：
Ding, Hu;Chen, Chen;Wang, Dao Wen
背景和目的——越来越多的证据表明，端粒长度是心血管系统生物衰老的一个因素。中风是否与通过端粒长度测量的加速生物衰老有关尚未得到最终证明。我们的目的是确定平均白细胞端粒长度是否是中风发生的预测因子。方法 - 通过定量聚合酶链反应测定 1309 名中风患者、1309 名年龄和性别匹配的对照受试者以及前瞻性随访 5 年的 858 名中风患者的白细胞相对端粒长度。对于每项测量，研究样本均分为四分位数。确定了端粒长度与中风风险以及中风后不良后果之间的关联。结果-中风患者的平均端粒长度明显短于对照受试者。在病例/对照样本中，较短的端粒长度水平与较高的中风风险直接相关。与第四个（最长）四分位数相比，缺血性中风风险的比值比 [OR]（和 95% 置信区间 [CI]）如下：第三个四分位数，1.37（1.04-1.82）；第二个四分位数，1.53 (1.17-2.02)；第一个四分位数为 2.12 (1.62-2.77)。对前瞻性队列患者的随访还表明，较短的端粒长度水平与所有原因的死亡率相关，但与中风复发无关。结论：较短的端粒长度与缺血性中风相关，是中风后死亡的强有力的预测因子。 （中风。2012；43：658-663。）
Background and Purpose-Accumulating evidence suggests that telomere length is a maker for biological aging of the cardiovascular system. Whether stroke is associated with accelerated biological aging as measured by telomere length has not been conclusively demonstrated. Our aim was to determine whether mean leukocyte telomere length is a predictor for the development of stroke.Methods-The relative telomere length of leukocytes was determined by quantitative polymerase chain reaction in 1309 stroke patients and 1309 age- and sex-matched control subjects as well as 858 stroke patients followed prospectively for 5 years. For each measure, the study sample was divided into quartiles. The associations between the telomere length and risk of stroke as well as poststroke adverse outcomes were determined.Results-Mean telomere length was significantly shorter in stroke patients than in control subjects. Shorter telomere length levels were directly associated with a higher risk of stroke in the case/control sample. As compared with the fourth (longest) quartile, the odd ratios [OR] (and 95% confidence intervals [CI]) for ischemic stroke risk were as follows: third quartile, 1.37 (1.04-1.82); second quartile, 1.53 (1.17-2.02); and first quartile, 2.12 (1.62-2.77). Follow-up of the patients from the prospective cohort also showed that shorter telomere length levels were associated with mortality from all causes but not with recurrence of stroke.Conclusions-Shorter telomere length was associated with ischemic stroke and was a strong predictor of poststroke death. (Stroke. 2012; 43: 658-663.)