Role of adenosine signaling in preeclampsia

Role of adenosine signaling in preeclampsia
复制标题

腺苷信号传导在先兆子痫中的作用

DOI:
10.1111/jog.15066
复制
发表时间:
2021
影响因子:
1.6
通讯作者:
Osuga Yutaka
Osuga Yutaka
中科院分区:
医学4区
文献类型:
--
作者:
Iriyama Takayuki;Sayama Seisuke;Osuga Yutaka

文献摘要

参考文献

相似文献

导致子痫前期(PE)病理生理学的胎盘特异性分子基础仍未完全清楚。腺苷是一种内源性核苷,是一种在低氧等病理条件下诱导的信号分子,参与多种疾病。最近在人类和动物模型上的证据表明,胎盘腺苷信号增强有助于PE的发展。本文就腺苷信号转导在PE病理生理学中的意义及针对腺苷信号转导治疗的前景作一综述。
Placenta‐specific molecular basis that is responsible for the pathophysiology of preeclampsia (PE) remains to be fully understood. Adenosine, an endogenous nucleoside, is a signaling molecule that is induced under pathological conditions such as hypoxia and is involved in various diseases. Recent evidence on humans and animal models has demonstrated that enhanced placental adenosine signaling contributes to the development of PE. This review is to summarize current progress and discuss the significance of adenosine signaling in the pathophysiology of PE and future perspectives of therapeutic possibilities targeting adenosine signaling.
先兆子痫血浆腺苷水平和血小板 P-选择素表达
DOI: --
发表时间: 2001
影响因子: 7.2
作者:
Y. Yoneyama;S. Suzuki;R. Sawa;Y. Kiyokawa;G. Power;T. Araki
通讯作者: T. Araki
DOI: 10.1172/jci15483
发表时间: 2003-09
期刊: The Journal of clinical investigation
影响因子: --
作者:
Y. Day;Liping Huang;M. Mcduffie;D. Rosin;H. Ye;Jiang-fan Chen;M. Schwarzschild;J. Fink;J. Linden;M. Okusa
通讯作者: Y. Day;Liping Huang;M. Mcduffie;D. Rosin;H. Ye;Jiang-fan Chen;M. Schwarzschild;J. Fink;J. Linden;M. Okusa
先兆子痫中人胎盘腺苷受体的表达升高,缺氧会增加 A2A 受体的表达。
DOI: 10.1016/j.placenta.2009.02.004
发表时间: 2009
期刊: Placenta
影响因子: 3.8
作者:
vonVersen-Höynck,F;Rajakumar,A;Bainbridge,SA;Gallaher,MJ;Roberts,JM;Powers,RW
通讯作者: Powers,RW
DOI: 10.1161/hypertensionaha.113.02458
发表时间: 2014-03
期刊: Hypertension (Dallas, Tex. : 1979)
影响因子: --
作者:
Wang W;Parchim NF;Iriyama T;Luo R;Zhao C;Liu C;Irani RA;Zhang W;Ning C;Zhang Y;Blackwell SC;Chen L;Tao L;Hicks MJ;Kellems RE;Xia Y
通讯作者: Xia Y
DOI: 10.1016/j.placenta.2014.06.369
发表时间: 2014-09-01
期刊: PLACENTA
影响因子: 3.8
作者:
Darashchonak, N.;Sarisin, A.;von Versen-Hoeynck, F.
通讯作者: von Versen-Hoeynck, F.