Predictors of Postoperative Quality of Life after Surgery for Lung Cancer
Predictors of Postoperative Quality of Life after Surgery for Lung Cancer
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DOI：
10.1097/jto.0b013e3182398e82
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发表时间：
2012-02-01
影响因子：
20.4
通讯作者：
Sartipy, Ulrik
中科院分区：
文献类型：
--
作者：
Moller, Axel;Sartipy, Ulrik
简介：目的是分析选定的患者变量和健康相关的生活质量6个月后手术肺癌。方法：在一项前瞻性的人群为基础的队列研究，SF-36（SF-36）被用来评估肺癌手术前和手术后6个月的生活质量。使用SF-36汇总和子量表评分的变化对两组6个月时与基线相比的生活质量进行分类（恶化或稳定/改善）。Logistic回归模型调整潜在的混杂因素被用来分析患者变量和术后6个月的生活质量之间的关联。结果：249例患者完成了基线SF-36问卷。排除了6个月时的无应答者（n = 36），14名在6个月随访前死亡的患者仍留在研究中，留下213名患者可用于分析。性别、合并症、术后并发症的发生和肿瘤分期与术后6个月生活质量的身体方面无关。切除程度、年龄和辅助治疗与术后6个月SF-36身体健康总分的临床相关下降显著相关。没有患者变量预测下降的精神成分汇总scores.Conclusions：切除的程度，年龄和辅助治疗与临床相关的下降，在身体方面的健康相关的生活质量手术后6个月。需要进一步的研究来探索可能的机制。
Introduction: The aim was to analyze the association between selected patient variables and health-related quality of life 6 months after surgery for lung cancer.Methods: In a prospective population-based cohort study, Short Form 36 (SF-36) was used to assess quality of life before and 6 months after surgery for lung cancer. The change in SF-36 summary and subscale scores were used to categorize quality of life in two groups (worse or stable/improved) at 6 months compared with baseline. Logistic regression models adjusting for potential confounding factors were used to analyze the association between patient variables and quality of life 6 months after surgery.Results: A baseline SF-36 questionnaire was completed by 249 patients. Nonresponders at 6 months (n = 36) were excluded, and 14 patients who died before 6 months follow-up remained in the study, leaving 213 patients available for analysis. Gender, comorbidity, occurrence of postoperative complications, and tumor stage were not associated with the physical aspect of quality of life 6 months after surgery. The extent of resection, age, and adjuvant therapy was significantly associated with a clinically relevant decline in the SF-36 physical component summary score 6 months postoperatively. No patient variables were predictive of a decline in the mental component summary score.Conclusions: The extent of resection, age, and adjuvant therapy was associated with a clinically relevant decline in the physical aspect of health-related quality of life 6 months after surgery. Further studies are needed to explore possible mechanisms.