Chromosomal abnormalities in human neoplasia.
Chromosomal abnormalities in human neoplasia.
复制标题
人类肿瘤中的染色体异常。
DOI：
--
复制
发表时间：
1970
影响因子：
10.5
通讯作者：
D. Hossfeld
中科院分区：
文献类型：
--
作者：
A. Sandberg;D. Hossfeld
这篇综述的主要目的是评估人类肿瘤的染色体变化，因为它们涉及三个重要领域：1。这种变化的特殊性; 2。从核型变异中收集到的信息可能会揭示人类肿瘤形成的更基本的过程和认识，以及3.染色体检查结果的临床适用性。为了完成这项任务，我们试图利用文献中发表的相关数据，并纳入了那些具有令人信服的和相对完整的临床，组织学和细胞遗传学数据的文章作为参考。没有尝试包括所有已发表的论文，不仅空间限制排除这样的方法，但往往文章包含太少的临床或细胞学信息，可靠地解释为本审查的目的。人类肿瘤性疾病的染色体变化似乎仅限于所涉及的组织，所有其他体细胞都是二倍体。偶然发生在肿瘤患者中的先天性核型异常，可能与癌症引起的染色体改变联合出现。在任何起源的癌症中，细胞遗传学异常仅见于原发肿瘤或其转移酶，而在白血病中，这些异常仅见于骨髓细胞或循环或其他器官中的白血病细胞。因此，在存在来自急性白血病患者的Phytohemagglutinin（PHA）的情况下，或来自慢性粒细胞白血病（CML）患者的皮肤成纤维细胞的情况下，来自血液淋巴细胞培养物的Meta相显示正常的二倍体图像，尽管在前一种情况下白血病细胞可能是非整倍体，而在后一种情况下骨髓细胞含有费城染色体（Ph 1）（1-35）。
The salient aims of this review will be to evaluate chromosomal changes in human neoplasia as they bear on three important areas: 1. the specificity of such changes ; 2. the information gleaned from karyotypic variations which may throw light upon the more fundamental processes and under standing of human neoplasia, and 3. the clinical applicability of chromosomal findings. To accomplish this task we have attempted to utilize the pertinent data published in the literature and have included for reference those articles which have cogent and relatively complete clinical, histologic, and cyto genetic data for the purposes of this review. No attempt has been made to include all published papers, for not only do limitations of space preclude such an approach, but often articles contain too scanty clinical or cytologic information to be reliably interpreted for the aims of this review. The chromosomal changes in human neoplastic disorders appear to be confined to the tissue involved, with all other somatic cells being diploid. Congenitally determined karyotypic abnormalities, coincidentally occurring in an occasional patient with neoplasia, may appear in consortium with the chromosomal changes caused by the cancer. In cancer of any origin the cytogenetic abnormalities are found only in the primary tumor or its me tastases, and in leukemia these abnormalities are encountered only in mar row cells or in the leukemic cells in the circulation or in other organs. Thus, meta phases from the culture of blood lymphocytes in the presence of phy tohemagglutinin (PHA) from patients with acute leukemia, or of skin fibro blasts from patients with chronic myelocytic leukemia (CML) , reveal a normal diploid picture, even though the leukemic cells may be aneuploid in the former condition and the marrow cells contain the Philadelphia chromosome (Ph1) in the latter (1-35) .