Role of the Perigenual Anterior Cingulate and Orbitofrontal Cortex in Contingency Learning in the Marmoset.
Role of the Perigenual Anterior Cingulate and Orbitofrontal Cortex in Contingency Learning in the Marmoset.
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DOI：
10.1093/cercor/bhw067
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发表时间：
2016-07
期刊：
影响因子：
--
通讯作者：
Roberts AC
中科院分区：
文献类型：
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作者：
Jackson SA;Horst NK;Pears A;Robbins TW;Roberts AC
两种学习机制有助于决策：目标导向的行动和“习惯”系统，通过该系统分别形成行动-结果和刺激-反应关联。啮齿动物损伤研究和人类神经影像学都暗示内侧前额叶皮层（mPFC）和眶额皮层（OFC）在应急学习的神经基础，目标导向的行动的关键组成部分，虽然一些发表的研究结果是相互矛盾的。我们试图调和现有的文献，通过比较兴奋性毒性病变的周围前扣带皮层（pgACC），一个区域的mPFC，和OFC的应急学习的绒猴使用触摸屏为基础的范例，其中一对行动和其结果之间的偶然关系被选择性地降解。pgACC和OFC病变组不敏感的应急退化，而对照组表现出选择性较高的性能相比，退化的行动时，非退化的行动。这些发现表明，pgACC和OFC都是必要的正常的应急学习，因此目标导向的行为。
Two learning mechanisms contribute to decision-making: goal-directed actions and the “habit” system, by which action-outcome and stimulus-response associations are formed, respectively. Rodent lesion studies and human neuroimaging have implicated both the medial prefrontal cortex (mPFC) and the orbitofrontal cortex (OFC) in the neural basis of contingency learning, a critical component of goal-directed actions, though some published findings are conflicting. We sought to reconcile the existing literature by comparing the effects of excitotoxic lesions of the perigenual anterior cingulate cortex (pgACC), a region of the mPFC, and OFC on contingency learning in the marmoset monkey using a touchscreen-based paradigm, in which the contingent relationship between one of a pair of actions and its outcome was degraded selectively. Both the pgACC and OFC lesion groups were insensitive to the contingency degradation, whereas the control group demonstrated selectively higher performance of the nondegraded action when compared with the degraded action. These findings suggest the pgACC and OFC are both necessary for normal contingency learning and therefore goal-directed behavior.