Familiarity for entities as a sensitive marker of antero-lateral entorhinal atrophy in amnestic mild cognitive impairment
Familiarity for entities as a sensitive marker of antero-lateral entorhinal atrophy in amnestic mild cognitive impairment
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DOI：
10.1016/j.cortex.2020.02.022
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发表时间：
2020-07-01
期刊：
影响因子：
3.6
通讯作者：
Bastin, Christine
中科院分区：
文献类型：
--
作者：
Besson, Gabriel;Simon, Jessica;Bastin, Christine
阿尔茨海默氏病（AD）痴呆症通常始于记忆缺陷。神经纤维缠结-AD的神经病理学标志之一-首先影响跨内嗅皮质（即，Brodmann区35 -BA 35和前外侧内嗅皮质），前外侧海马旁区的一个亚区（也包括BA 36），目前假设作为代表实体的功能枢纽。在这里，我们通过研究前外侧海马旁亚区的萎缩是否会影响对实体的记忆来验证这一假设。遗忘型轻度认知障碍患者（aMCI;已知处于AD的高风险中并且呈现可变的前外侧海马旁萎缩; N1/417）和健康的老年对照参与者（N1/417）进行了前外侧海马旁亚区的高分辨率MRI扫描和视觉物体熟悉性任务，批判性地包括三个条件，以增加对实体级表征的需求：（1）让所有流畅性线索有助于熟悉，（2）排除概念流畅性，（3）也排除知觉流畅性，从而直接利用实体的熟悉性。在aMCI中，右前外侧内嗅皮层特别有助于熟悉实体，这种关联比“区分”条件下的熟悉性更强（2）（也排除了概念流畅性，但按照传统以观点依赖的方式进行测试）。相比之下，右BA 36特别有助于在辨别性条件下的熟悉度，这种关联似乎略强于熟悉实体。这些结果揭示了新的功能层次，可能存在于前外侧海马旁枢纽。重要的是，需要实体水平代表的熟悉性可能专门针对经内嗅完整性，为开发仍然缺乏的AD相关初始衰退的临床标志物开辟了一条有希望的途径。(c)2020爱思唯尔有限公司版权所有。
Alzheimer's disease (AD) symptomatology typically starts with memory deficits. Neurofi- brillary tangles - one of the neuropathological hallmarks of AD - first affect the trans- entorhinal cortex (i.e., Brodmann's area 35 - BA35 and antero-lateral entorhinal cortex), a subregion of the antero-lateral parahippocampal region (also comprising BA36) currently hypothesized to serve as a functional hub representing entities. Here, we tested this hy- pothesis by investigating whether atrophy of antero-lateral parahippocampal subregions affects memory for entities. Patients with amnestic mild cognitive impairment (aMCI; known to be at high -risk of AD and to present with variable antero-lateral parahippocampal atrophy; N 1 / 4 17) and healthy older control participants (N 1 / 4 17) underwent a high -resolution MRI scan of the antero-lateral parahippocampal subregions and a visual object familiarity task, critically including three conditions with increasing need for entity -level representa- tion: (1) letting all fluency cues contribute to familiarity, (2) precluding conceptual fluency, and (3) also precluding perceptual fluency, thereby directly tapping familiarity for entities. In aMCI, right antero-lateral entorhinal cortex specifically contributed to familiarity for en- tities, an association that was stronger than with familiarity in the 'discriminative' condi- tion (2) (also precluding conceptual fluency, but tested in a viewpoint -dependent fashion as traditionally). In contrast, right BA36 specifically contributed to familiarity in the discrimi- native condition, an association that appeared marginally stronger than with familiarity for entities. These results shed new light on the functional hierarchy that may exist within the antero-lateral parahippocampal hub. Importantly, familiarity requiring an entity -level rep- resentation may specifically target transentorhinal integrity, opening a promising avenue to develop the still -lacking clinical marker of AD -related initial decline. (c) 2020 Elsevier Ltd. All rights reserved.