Corticosteroid Sparing Effect of Hachimijiogan in Mikulicz's Disease:A Case Report
Corticosteroid Sparing Effect of Hachimijiogan in Mikulicz's Disease:A Case Report
复制标题
Hachimijiogan 对 Mikulicz 病的皮质类固醇节约作用：一例报告
DOI：
10.3937/kampomed.60.513
复制
发表时间：
2009
期刊：
影响因子：
--
通讯作者：
T. Hanawa
中科院分区：
文献类型：
--
作者：
T. Tsuda;S. Yashiro;Yuji Gamo;W. Watanabe;T. Hoshino;S. Hyuga;T. Oikawa;T. Hanawa
一位65岁女性于2005年7月因腮腺及下颌下腺肿胀，并于2005年10月出现眼及口腔干燥。2006年6月，我们根据头部磁共振成像、镓造影和嘴唇活检诊断她患有米库利奇病。在开始泼尼松龙10 mg/天治疗后，她的唾液腺轻微萎缩。虽然泼尼松龙的量在2007年5月前逐渐减少至7 mg/天，但她的血清IgG反弹。2008年1月，推出了Hachimijiogan提取物颗粒7.5克/天。唾液腺肿胀消失，血清IgG水平下降。2008年5月，泼尼松龙的剂量成功逐渐减少至6 mg/天。米库利奇病是一种皮质类固醇敏感性疾病，但在这种情况下，类固醇耐药性使治疗困难。基于此，我们用钙黄绿素-AM进行了P-糖蛋白的功能测定，证明了八爪鱼肝可以逆转耐药性。
A 65-year-old woman suffered from swollen parotid and submandibular glands in July 2005, and sicca of the eyes and oral cavity arose in October 2005. We diagnosed her as having Mikulicz's disease based on magnetic resonance imaging of the head, gallium scintigraphy, and a lip biopsy in June 2006. After prednisolone 10 mg/day was commenced, her salivary glands shrank slightly. Although the amount of prednisolone had been tapered to 7 mg/day by May 2007, her serum IgG rebounded. In January 2008, hachimijiogan extract granules 7.5 g/day were introduced. Swelling of the salivary glands disappeared and her serum IgG level decreased. In May 2008, the amount of prednisolone was tapered successfully to 6 mg/day. Mikulicz's disease is a corticosteroid-sensitive disease, but in this case steroid resistance made treatment difficult. Based on this case, we performed functional assays of P-glycoprotein with calcein-AM, which demonstrated that hachimijiogan can reverse drug resistance.
淋巴细胞中白介素2对多药耐药1基因的转录调控。
DOI：
--
发表时间：
2004
期刊：
Gene to Cells 9巻
影响因子：
--
作者：
Tsujimura;S.
通讯作者：
S.