Sensor, a population-based cohort study on gastroenteritis in the Netherlands:: Incidence and etiology
Sensor, a population-based cohort study on gastroenteritis in the Netherlands:: Incidence and etiology
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DOI：
10.1093/aje/154.7.666
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发表时间：
2001-10-01
影响因子：
5
通讯作者：
van Duynhoven, YTHF
中科院分区：
文献类型：
--
作者：
de Wit, MAS;Koopmans, MPG;van Duynhoven, YTHF
进行了一项基于人群的前瞻性队列研究和巢式病例对照研究，以估计荷兰普通人群中胃肠炎和相关病原体的发病率。从1998年12月至1999年12月，通过每周报告卡对两个连续队列进行随访。病例对照研究中的病例和对照提供了调查问卷和粪便样本。标准化胃肠炎发病率为283/1000人-年。发病率随着教育水平的提高而上升，有腹泻史的人和幼儿的发病率更高。细菌病原体占病例的5%，细菌毒素占9%，寄生虫占6%，病毒病原体占21%，其中诺瓦克样病毒（NLV）是11%病例的主要病原体。胃肠炎的发病率高于英国报告的发病率，但低于美国。在社区病例中，病毒病原体是胃肠炎的主要原因，NLV是除一个年龄组外所有年龄组的头号致病原因。在许多国家，实施预防措施以减少细菌感染。然而，对病毒感染的额外预防，特别是NLV，可能会显着减少社区胃肠炎病例的数量。
A prospective population-based cohort study with a nested case-control study was conducted to estimate the incidence of gastroenteritis and the associated pathogens in the general Dutch population. Follow-up of two consecutive cohorts was performed by weekly reporting cards from December 1998 to December 1999. Cases and controls in the case-control study supplied a questionnaire and stool samples. The standardized gastroenteritis incidence was 283 per 1,000 person-years. The incidence rose with increasing level of education and was higher for persons with a history of diarrhea and for young children. Bacterial pathogens accounted for 5% of cases, bacterial toxins for 9%, parasites for 6%, and viral pathogens for 21%, with Norwalk-like virus (NLV) as the leading pathogen in 11% of cases. The gastroenteritis incidence was higher than that reported for England, but lower than for the United States. In community cases, viral pathogens are the leading cause of gastroenteritis, with NLV being the number one cause of illness in all age groups but one. In many countries, preventive measures are implemented to decrease bacterial infections. However, additional prevention of viral infections, especially NLV, might significantly decrease the number of gastroenteritis cases in the community.