Cell signaling and transcription factors regulating cell fate during formation of the mouse blastocyst.
Cell signaling and transcription factors regulating cell fate during formation of the mouse blastocyst.
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DOI：
10.1016/j.tig.2015.04.002
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发表时间：
2015-07
期刊：
影响因子：
--
通讯作者：
Ralston A
中科院分区：
文献类型：
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作者：
Frum T;Ralston A
哺乳动物发育过程中的第一个细胞命运决定建立了健康妊娠所必需的组织。小鼠已成为发现调节第一个细胞命运决定的途径的有价值的模型，因为早期胚胎可以很容易地恢复，并且有一系列经典和新兴的操纵基因表达的方法。在这里，我们总结了控制小鼠发育中第一个细胞命运决定的主要途径。这些知识可以作为探索自组织系统的新兴特性如何动态调节基因表达和细胞命运可塑性的范例。此外，它还揭示了建立健康妊娠和胚胎干 (ES) 细胞的过程。我们还描述了未解之谜和有助于克服该领域实验挑战的新技术。
The first cell fate decisions during mammalian development establish tissues essential for healthy pregnancy. The mouse has served as a valuable model for discovering pathways regulating the first cell fate decisions, because of the ease with which early embryos can be recovered and an arsenal of classical and emerging methods for manipulating gene expression. Here we summarize the major pathways that govern the first cell fate decisions in mouse development. This knowledge serves as a paradigm for exploring how emergent properties of a self-organizing system can dynamically regulate gene expression and cell fate plasticity. Moreover, it brings to light the processes that establish healthy pregnancy and embryonic stem (ES) cells. We also describe unsolved mysteries and new technologies that could help overcome experimental challenges in the field.