Standardization of insulin immunoassays: Report of the American Diabetes Association Workgroup

Standardization of insulin immunoassays: Report of the American Diabetes Association Workgroup
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DOI:
10.1373/clinchem.2006.082214
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发表时间:
2007-04-01
期刊:
影响因子:
9.3
通讯作者:
Steffes, Michael W.
Steffes, Michael W.
中科院分区:
医学1区
文献类型:
--
作者:
Marcovina, Santica;Bowsher, Ronald R.;Steffes, Michael W.

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背景资料:血清或血浆中的循环胰岛素浓度为估计胰岛素分泌和胰岛素抵抗提供了重要信息。方法:由美国糖尿病协会召集的一个工作组评估了9家生产商的12种不同的商业胰岛素方法。结果:10种方法中有7种方法的批内CV范围为3.7%-39.0%,其中12种方法的批内CV范围为3.7%-39.0%。结果:10种方法中有7种方法的批内CV范围为3.7%-39.0%。结果:10种
Background: Circulating insulin concentration in serum or plasma provides important information for the estimation of insulin secretion and insulin resistance. Currently, lack of standardization of insulin assays hinders efforts to achieve consistent measures for treatment guidelines.Methods: A Workgroup convened by the American Diabetes Association evaluated 12 different commercial insulin methods from 9 manufacturers.Results: The within-assay CVs ranged from 3.7% to 39.0%, with 7 of 10 assays having a CV