Protection against Japanese encephalitis virus strains representing four genotypes by passive transfer of sera raised against ChimeriVax™-JE experimental vaccine
Protection against Japanese encephalitis virus strains representing four genotypes by passive transfer of sera raised against ChimeriVax™-JE experimental vaccine
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DOI：
10.1016/j.vaccine.2004.03.027
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发表时间：
2004-09-09
期刊：
影响因子：
5.5
通讯作者：
Barrett, ADT
中科院分区：
文献类型：
--
作者：
Beasley, DWC;Li, L;Barrett, ADT
评估了针对候选日本脑炎病毒(JEV)疫苗ChimeriVax(TM)-JE和目前获得许可的JE-VAX(R)疫苗对代表四种主要基因类型的JEV毒株的保护能力。小鼠的中和试验和被动保护研究表明，对基因II和III型菌株提供了最大的保护，但对I型和IV型菌株也有一定的保护作用。Chimerivax(商标)-JE刺激性保护与JE-VAX(R)对照相当或更好。(C)2004爱思唯尔有限公司。保留所有权利。
The ability of antiscra raised against a candidate Japanese encephalitis virus (JEV) vaccine, ChimeriVax(TM)-JE, and the currently licensed vaccine, JE-VAX(R), to protect against strains of JEV representing the four major genotypes was assessed. Neutralization assays and passive protection studies in mice showed that greatest protection was provided against strains of genotypes II and III, although some protection was also afforded against genotypes I and IV strains. Chimerivax(TM)-JE stimulated protection that was comparable or superior to the JE-VAX(R) control. (C) 2004 Elsevier Ltd. All rights reserved.