Regulated aberrant amygdala functional connectivity in premenstrual syndrome via electro-acupuncture stimulation at sanyinjiao acupoint(SP6?
Regulated aberrant amygdala functional connectivity in premenstrual syndrome via electro-acupuncture stimulation at sanyinjiao acupoint(SP6?
复制标题
DOI：
10.1080/09513590.2020.1855633
复制
发表时间：
2020-12-12
影响因子：
2
通讯作者：
Deng, Demao
中科院分区：
文献类型：
--
作者：
Pang, Yong;Liao, Hai;Deng, Demao
背景：针灸是治疗经前综合征的有效方法。然而，这种方法背后的机制仍然不清楚。我们先前的研究发现，异常的杏仁核静息状态功能网络参与了经前综合征的发生。因此，深入研究针刺刺激引起的杏仁核静息功能网络的改变，有助于更好地了解针刺治疗经前综合征的复杂机制。方法：选择经前综合征患者23例。所有患者均在三阴交穴位进行6min的电针刺激，并在电针刺激前后进行两次6min的静息fMRI扫描。以杏仁核为种子区，采用功能连接性(FC)方法检测经前综合征患者EAS相关的内在连接性调节。结果：EAS刺激SP6可增加左侧杏仁核与脑干、右侧海马区的FC，降低左侧杏仁核与左侧丘脑、双侧辅助运动区(SMA)的FC。此外，电刺激SP6可引起右侧杏仁核与脑干、右侧海马、右侧眶前叶皮质、双侧扣带回前部的FC增加，右侧杏仁核与右侧SMA之间的FC降低。结论：在前期研究的基础上，我们的研究结果可能有助于我们更好地理解针刺治疗经前综合征的神经机制。
Background: Acupuncture is an effective therapy for premenstrual syndrome (PMS). However, the mechanisms behind this method are still unclear. Our previous study found that aberrant amygdala resting-state functional networks were involved in PMS. Thereby, a deep investigation on the alterations of amygdala resting-state functional networks induced by acupuncture stimulation might contribute to a better understanding of the intricate mechanisms of acupuncture treatment on PMS.Methods: Twenty three PMS patients were recruited in this study. All patients received a 6-minute electro-acupuncture stimulation (EAS) at Sanyinjiao acupoint (SP6) and underwent two 6-minute resting-state fMRI scannings before and after EAS. With amygdala as the seed region, functional connectivity (FC) method was adopted to examine EAS-related modulation of intrinsic connectivity in PMS patients by comparing pre-EAS.Results: The results showed that EAS at SP6 induced increased FC between the left amygdala and brainstem, right hippocampus, and decreased FC between the left amygdala and left thalamus, bilateral supplementary motor area (SMA). Moreover, the results also showed that EAS at SP6 induced increased FC between the right amygdala and brainstem, right hippocampus, right orbitofrontal cortex, bilateral anterior cingulate cortex (ACC), and decreased FC between the right amygdala and right SMA.Conclusions: Based on the results of our previous study, our findings might improve our understanding of neural mechanisms behind acupuncture effects on PMS.