The Trajectory of the COVID-19 Vaccine Antibody Titers Over Time and the Association of Mycophenolate Mofetil in Solid Organ Transplant Recipients.
The Trajectory of the COVID-19 Vaccine Antibody Titers Over Time and the Association of Mycophenolate Mofetil in Solid Organ Transplant Recipients.
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DOI：
10.1016/j.transproceed.2022.10.023
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发表时间：
2022-12
影响因子：
0.9
通讯作者：
Matsunami H
中科院分区：
文献类型：
--
作者：
Sakai A;Morishita T;Suzumura K;Hanatate F;Yoshikawa T;Sasaki N;Lee S;Fujita K;Hara T;Araki H;Tagami A;Murayama M;Yamada R;Iwata A;Sobajima T;Kasahara Y;Matsuzawa Y;Takemura M;Yamamoto Y;Fujigaki H;Saito K;Tsurumi H;Matsunami H
COVID-19疫苗将对实体器官移植受者（SOT）安全有效。然而，钝化的抗体反应也是令人担忧的。很少有研究报告SOT患者接种2剂BNT 162 b2疫苗后血清学随访时间延长。我们对78名接受2剂BNT 162 b2疫苗的SOT进行了一项单中心、前瞻性观察性研究。我们确定了接种后的抗体滴度的轨迹之间的SOT有或没有霉酚酸酯（MMF）或从MMF撤出。我们发现，在接受MMF治疗的SOT中，血清转换率较低（29/42：69%），抗体滴度较低。在限制性三次样条图中证实了中和抗体滴度与MMF浓度之间的逆线性关系（效应P <0.01，非线性P = 0.08）。对于抗体应答的轨迹，在接种2剂疫苗后首次访视时显示血清阴性或低抗体滴度的SOT中，在停用MMF后观察到血清转换和抗体滴度改善（效应P < .01，非线性P < .05，相互作用P < .01）。我们发现停用MMF后B细胞计数增加（P <0.01）。在从MMF中撤出的SOT中观察到抗体应答恢复。抗体应答的轨迹通过给予MMF而改变。
The COVID-19 vaccine will be safe and effective in solid organ transplant recipients (SOTs). However, the blunted antibody responses were also of concern. Few studies have reported prolonged serologic follow-up after 2 doses of BNT162b2 vaccine in SOTs. We performed a single-center, prospective observational study of 78 SOTs who received 2 doses of BNT162b2 vaccine. We identified the trajectory of antibody titers after vaccination among SOTs with or without mycophenolate mofetil (MMF) or withdrawn from MMF. We found low seroconversion rates (29/42: 69%) and low antibody titers in SOTs treated with MMF. An inverse linear relationship between neutralizing antibody titers and MMF concentration was confirmed in restricted cubic spline plots (P for effect < .01, P for nonlinearity = .08). For the trajectory of antibody responses, seroconversion and improved antibody titers were observed after withdrawal from MMF in SOTs who showed seronegative or low antibody titers at the first visit after 2 doses of vaccine (P for effect < .01, P for nonlinearity < .05, and P for interaction < .01). We identified increased B-cell counts after withdrawal from MMF (P < .01). The recovery of antibody responses was seen in SOTs withdrawn from MMF. The trajectories of antibody responses were modified by MMF administration.
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BNT162B2 mRNA COVID-19疫苗的安全性和功效。
DOI：
10.1056/nejmoa2034577
发表时间：
2020-12-31
期刊：
The New England journal of medicine
影响因子：
--
作者：
Polack FP;Thomas SJ;Kitchin N;Absalon J;Gurtman A;Lockhart S;Perez JL;Pérez Marc G;Moreira ED;Zerbini C;Bailey R;Swanson KA;Roychoudhury S;Koury K;Li P;Kalina WV;Cooper D;Frenck RW Jr;Hammitt LL;Türeci Ö;Nell H;Schaefer A;Ünal S;Tresnan DB;Mather S;Dormitzer PR;Şahin U;Jansen KU;Gruber WC;C4591001 Clinical Trial Group
通讯作者：
C4591001 Clinical Trial Group
DOI：
10.1016/s2665-9913(21)00222-8
发表时间：
2021-11
期刊：
The Lancet. Rheumatology
影响因子：
--
作者：
Boekel L;Steenhuis M;Hooijberg F;Besten YR;van Kempen ZLE;Kummer LY;van Dam KPJ;Stalman EW;Vogelzang EH;Cristianawati O;Keijzer S;Vidarsson G;Voskuyl AE;Wieske L;Eftimov F;van Vollenhoven R;Kuijpers TW;van Ham SM;Tas SW;Killestein J;Boers M;Nurmohamed MT;Rispens T;Wolbink G
通讯作者：
Wolbink G
DOI：
10.1056/nejmoa2200674
发表时间：
2022-05-19
期刊：
The New England journal of medicine
影响因子：
--
作者：
通讯作者：
--
影响因子：
27.4
作者：
Mrak, Daniel;Tobudic, Selma;Bonelli, Michael
通讯作者：
Bonelli, Michael
影响因子：
25.7
作者：
Rabinowich L;Grupper A;Baruch R;Ben-Yehoyada M;Halperin T;Turner D;Katchman E;Levi S;Houri I;Lubezky N;Shibolet O;Katchman H
通讯作者：
Katchman H