Well-Differentiated Papillary Mesothelioma of the Peritoneum Is Genetically Distinct from Malignant Mesothelioma
Well-Differentiated Papillary Mesothelioma of the Peritoneum Is Genetically Distinct from Malignant Mesothelioma
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DOI：
10.3390/cancers12061568
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发表时间：
2020-06-01
期刊：
影响因子：
5.2
通讯作者：
Churg, Andrew
中科院分区：
文献类型：
--
作者：
Shrestha, Raunak;Nabavi, Noushin;Churg, Andrew
Well-differentiated papillary mesothelioma (WDPM) is an uncommon mesothelial proliferation that is most commonly encountered as an incidental finding in the peritoneal cavity. There is controversy in the literature about whether WDPM is a neoplasm or a reactive process and, if neoplastic, whether it is a variant or precursor of epithelial malignant mesothelioma or is a different entity. Using whole exome sequencing of five WDPMs of the peritoneum, we have identified distinct mutations inEHD1,ATM,FBXO10,SH2D2A,CDH5,MAGED1, andTP73shared by WDPM cases but not reported in malignant mesotheliomas. Furthermore, we show that WDPM is strongly enriched with C > A transversion substitution mutations, a pattern that is also not found in malignant mesotheliomas. The WDPMs lacked the alterations involvingBAP1,SETD2,NF2,CDKN2A/B,LASTS1/2,PBRM1, andSMARCC1that are frequently found in malignant mesotheliomas. We conclude that WDPMs are neoplasms that are genetically distinct from malignant mesotheliomas and, based on observed mutations, do not appear to be precursors of malignant mesotheliomas.
