CD1a expression in PEComas
CD1a expression in PEComas
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DOI：
10.1111/j.1440-1827.2007.02206.x
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发表时间：
2008-03-01
影响因子：
2.2
通讯作者：
Hayashi, Kazuhiko
中科院分区：
文献类型：
--
作者：
Adachi, Yoshin;Horie, Yasushi;Hayashi, Kazuhiko
根据世界卫生组织的分类，血管周围上皮样细胞分化肿瘤（PEComas）是由组织学和化学特征独特的PEC组成的间叶性肿瘤。一般来说，几乎所有的PEComa对黑素细胞（HMB-45和/或黑素A）和平滑肌（肌动蛋白（SMA）和/或结蛋白）标记物都具有免疫反应性。近年来，作者报道肺良性透明细胞糖瘤（PEComa之一）表达CD 1a。因此，本研究的目的是探讨PEComa和CD 1a表达之间的关系。结果19例患者均获确诊，包括肾或肝血管平滑肌脂肪瘤、子宫或肺淋巴管平滑肌瘤病和肺透明细胞糖瘤。18个肿瘤有α-SMA和HMB-45表达，16个有黑色素A表达。相反，所有19个肿瘤都有CD 1a表达。目前的研究证实，在许多情况下PEComa的CD 1a表达。这些数据表明，CD 1a的表达可以是一个额外的新的标记PEComa，也支持不同的和完整的疾病实体的PEComa。
According to the World Health Organization classification, neoplasms with perivascular epithelioid cell differentiation (PEComas) are mesenchymal tumors composed of histologically and immunohistochemically distinctive PEC. Generally, nearly all PEComas have immunoreactivity for both melanocytic (HMB-45 and/or melan A) and smooth muscle (actin (SMA) and/or desmin) markers. Recently the authors reported that benign clear cell sugar tumor of the lung, one of the PEComas, expressed CD1a. Therefore the purpose of the present study was to investigate the relationship between PEComas and CD1a expression. Nineteen PEComas were obtained, which included angiomyolipoma of the kidney or liver, lymphangiomyomatosis of the uterus or lung and clear cell sugar tumor of the lung. Eighteen tumors had alpha-SMA and HMB-45 expression and 16 had melan A expression. In contrast, all 19 tumors had CD1a expression. The present study confirms CD1a expression in many cases of PEComa. These data suggest that CD1a expression can be an additional new marker for PEComas and also supports the distinct and integrated disease entity of PEComas.