Protective Effect of Panax ginseng extract on Renal Functions Altered by Mercuric Chloride in Albino Rats
Protective Effect of Panax ginseng extract on Renal Functions Altered by Mercuric Chloride in Albino Rats
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人参提取物对氯化汞所致白化大鼠肾功能的保护作用
DOI：
10.5142/jgr.2006.30.3.100
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发表时间：
2006
影响因子：
6.3
通讯作者：
Ashok Kumar
中科院分区：
文献类型：
--
作者：
P. N. Saxena;K. Mahour;Ashok Kumar
肝和肾是特定的器官，在生物转化和解毒机制中发挥着积极的作用。化学物质或重金属的不利影响可导致这些机制的延迟或消退。本研究旨在探讨人参提取物对氯化汞(重金属)所致大鼠肾功能的保护作用。将50只大白鼠随机分为10组。急性研究的五组和亚急性研究的五组。对照组(吐温20加蒸馏水)，氯化汞治疗组(急性组0.926㎎/㎏体重，亚急性组0.044㎎/㎏体重计算LD？)(9.26㎎/㎏体重)。根据概率分析(Finney，1971)？，人参提取物治疗组(急性和亚急性发作10㎎/㎏体重)、氯化汞治疗后人参提取物和人参提取物再氯化汞组。所有剂量均经灌胃管灌胃给药。结果表明，急性和亚急性治疗后，氯化汞治疗组大鼠血清尿素、肌酐显著升高，人参提取物组显著降低(P<0.01)。生化测定也从肾脏病理角度得到了印证。但人参提取液加氯化汞处理组较氯化汞处理加人参提取液组更为显著。结论：人参提取物对氯化汞中毒大鼠的肾功能具有保护作用。
Liver and kidney are specific organs which play an active role in biotransformation and detoxification mechanisms. Ant adverse effect of chemicals or heavy metal can cause the delay or fade in these mechanisms. Present study was designed to find out the protective effect of Panax ginseng extract on renal functions altered by mercuric chloride (heavy metal) in albino rat. Fifty albino rats were divided into 10 groups. Five groups for acute study and five groups for sud-acute study viz. control group (Tween 20 and distilled water), mercuric chloride treated group (0.926 ㎎/㎏ body wt. for acute and 0.044 ㎎/㎏ body wt. for sub-acute group after calculated LD?? (9.26 ㎎/㎏ body wt.) by probit analysis (Finney, 1971)¹, Panax ginseng extract treated group (10 ㎎/㎏ body wt. for acute and sub-acute sets), mercuric chloride treated followed by Panax ginseng extract and Panax ginseng extract followed by mercuric chloride group. All doses were given orally by gavage tube. The result revealed that the serum urea and creatinine significantly increased in mercuric chloride treated group, while significantly decreased (p＜0.01) in Panax ginseng extract group after acute and sub-acute treatment. The biochemical estimation is also confirmed by nephropathological aspect. However, the Panax ginseng extract treated followed by mercuric chloride group is more prominent than the mercuric chloride treated followed by Panax ginseng extract group. It can be concluded that Panax ginseng extract had a protective nature on renal functions against mercuric chloride toxicity in albino rats.