Characterization of Extensively Drug-Resistant Mycobacterium tuberculosis Clinical Isolates in China
Characterization of Extensively Drug-Resistant Mycobacterium tuberculosis Clinical Isolates in China
复制标题
中国广泛耐药结核分枝杆菌临床分离株的特征
DOI：
10.1128/jcm.00822-08
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发表时间：
2008-12-01
影响因子：
9.4
通讯作者：
Li, Chuanyou
中科院分区：
文献类型：
--
作者：
Sun, Zhaogang;Chao, Yanjie;Li, Chuanyou
从我国1,926株结核病临床分离株中鉴定出13株广泛耐药结核菌，这些菌株对广谱抗结核药物高度耐药。它们具有高度多样的分枝杆菌散布的重复单位可变数目串联重复模式。大多数（但不是全部）药物靶基因具有导致对相应药物耐药性的突变。
Thirteen extensively drug-resistant tuberculosis isolates which were highly resistant to a broad spectrum of antituberculosis drugs were identified from 1,926 clinical isolates in China. They had highly diverse mycobacterial interspersed repetitive-unit-variable-number tandem-repeat patterns. Most, but not all, of the drug target genes had mutations contributing to resistance to the corresponding drug.