Chalcogen Bonds Involving Selenium in Protein Structures.
Chalcogen Bonds Involving Selenium in Protein Structures.
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DOI:
10.1021/acschembio.1c00441
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发表时间:
2021-09-17
影响因子:
4
通讯作者:
Metrangolo P
中科院分区:
文献类型:
--
作者:
Carugo O;Resnati G;Metrangolo P
Chalcogen bonds are the specific interactions involving group 16 elements as electrophilic sites. The role of chalcogen atoms as sticky sites in biomolecules is underappreciated, and the few available studies have mostly focused on S. Here, we carried out a statistical analysis over 3562 protein structures in the Protein Data Bank (PDB) containing 18 266 selenomethionines and found that Se···O chalcogen bonds are commonplace. These findings may help the future design of functional peptides and contribute to understanding the role of Se in nature.
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发表时间:
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期刊:
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