Sunflower Oil but Not Fish Oil Resembles Positive Effects of Virgin Olive Oil on Aged Pancreas after Life-Long Coenzyme Q Addition
Sunflower Oil but Not Fish Oil Resembles Positive Effects of Virgin Olive Oil on Aged Pancreas after Life-Long Coenzyme Q Addition
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DOI：
10.3390/ijms161023425
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发表时间：
2015-10-01
影响因子：
5.6
通讯作者：
Quiles, Jose L.
中科院分区：
文献类型：
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作者：
Gonzalez-Alonso, Adrian;Ramirez-Tortosa, Cesar L.;Quiles, Jose L.
适当的胰腺结构是最佳器官功能所必需的。结构变化在年龄相关性胰腺疾病的发展中至关重要。在这种情况下，据报道，根据消耗的脂肪组成，大鼠的不同胰腺隔室受到影响。由于线粒体、氧化应激和衰老之间存在密切关系，因此已经开发了一种实验方法来更深入地了解胰腺中的这一过程。在大鼠中终生给予低剂量的辅酶Q，以试图预防与某些膳食脂肪来源相关的胰腺衰老相关的改变。据此，三组大鼠被喂食含有辅酶Q（CoQ）的正常热量饮食两年，其中包括初榨橄榄油，向日葵油或鱼油作为唯一的脂肪来源。在人道处死时采集用于显微镜检查的胰腺样本和血液样本。主要的发现是，辅酶Q补充剂根据饮食中使用的脂肪产生不同的结果。当向日葵籽油是饮食中的主要脂肪时，辅酶Q补充剂似乎可以改善内分泌胰腺结构，特别是-细胞质量，类似于初榨橄榄油的积极作用。相反，辅酶Q摄入似乎并没有改善以前观察到的鱼油喂养大鼠的外分泌室的结构改变。因此，辅酶Q可能会改善胰腺的变化与慢性摄入某些膳食脂肪来源。
An adequate pancreatic structure is necessary for optimal organ function. Structural changes are critical in the development of age-related pancreatic disorders. In this context, it has been reported that different pancreatic compartments from rats were affected according to the fat composition consumed. Since there is a close relationship between mitochondria, oxidative stress and aging, an experimental approach has been developed to gain more insight into this process in the pancreas. A low dosage of coenzyme Q was administered life-long in rats in order to try to prevent pancreatic aging-related alterations associated to some dietary fat sources. According to that, three groups of rats were fed normocaloric diets containing Coenzyme Q (CoQ) for two years, where virgin olive, sunflower, or fish oil was included as unique fat source. Pancreatic samples for microscopy and blood samples were collected at the moment of euthanasia. The main finding is that CoQ supplementation gives different results according to fat used in diet. When sunflower oil was the main fat in the diet, CoQ supplementation seems to improve endocrine pancreas structure and in particular -cell mass resembling positive effects of virgin olive oil. Conversely, CoQ intake does not seem to improve the structural alterations of exocrine compartment previously observed in fish oil fed rats. Therefore CoQ may improve pancreatic alterations associated to the chronic intake of some dietary fat sources.