Purinergic regulation of mast cell function: P2X4 receptor-mediated enhancement of allergic responses
Purinergic regulation of mast cell function: P2X4 receptor-mediated enhancement of allergic responses
复制标题
肥大细胞功能的嘌呤能调节：P2X4 受体介导的过敏反应增强
DOI：
10.1016/j.jphs.2022.07.005
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发表时间：
2022
影响因子：
3.5
通讯作者：
Ito Masa-aki
中科院分区：
文献类型：
--
作者：
Matsuoka Isao;Yoshida Kazuki;Ito Masa-aki
三磷酸腺苷（ATP）最初作为一种神经递质引起人们的关注，人们对自主神经和中枢神经系统中神经传递的调节进行了大量研究。ATP也是所有活细胞中丰富的能量货币，并通过各种调节机制释放到细胞外空间。ATP和相关的嘌呤和嘧啶核苷酸作为细胞外信号传导分子在调节免疫细胞功能中的作用已被报道为嘌呤能信号传导的证据，并已成为关注的焦点，作为各种疾病的治疗靶点。肥大细胞（MC）分布在与外界环境接触的组织中，是最早对非微生物环境抗原产生应答的免疫细胞。虽然细胞外ATP被认为是MCs的激活剂，但其细节仍有待研究。本文就离子型P2X4受体信号在MC功能中的独特作用作一综述。嘌呤能信号的作用可能与各种生理、化学和物理刺激联合存在。P2X4受体介导的行动在这篇文章中所描述的MC的特点可能会提供线索，以揭示以前未知的嘌呤能信号诱导的影响。
Adenosine triphosphate (ATP) initially attracted attention as a neurotransmitter, with much research conducted on the regulation of neurotransmission in the autonomic and central nervous systems. ATP is also abundant as an energy currency in all living cells and is released into extracellular spaces by various regulated mechanisms. The role of ATP and related purine and pyrimidine nucleotides as extracellular signaling molecules in the regulation of immune cell functions has been reported as evidence for purinergic signaling and has become the focus of attention as therapeutic targets for various diseases. Mast cells (MCs) are distributed in tissues in contact with the outside environment and are the first immune cells to respond to non-microbial environmental antigens. Although extracellular ATP is known as an activator of MCs, the details remain to be investigated. Based on our series of studies, this review describes the unique features of ionotropic P2X4 receptor signals in MC functions. The role of purinergic signaling may exist in combination with various physiological, chemical and physical stimuli. The characteristics of P2X4 receptor-mediated action in MCs described in this article may provide clues to reveal the previously unknown effects induced by purinergic signaling.