Blockade of adenosine A2A receptors by SCH 58261 results in neuroprotective effects in cerebral ischaemia in rats
Blockade of adenosine A2A receptors by SCH 58261 results in neuroprotective effects in cerebral ischaemia in rats
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DOI：
10.1097/00001756-199812010-00034
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发表时间：
1998-12-01
期刊：
影响因子：
1.7
通讯作者：
Ongini, E
中科院分区：
文献类型：
--
作者：
Monopoli, A;Lozza, G;Ongini, E
阻断腺苷受体可减少全脑缺血模型的脑梗死面积。使用有效的选择性A（2A）腺苷受体拮抗剂SCH 58261，我们评估了A（2A）受体是否参与阻塞左侧大脑中动脉引起的局灶性脑缺血后的神经元损伤。SCH 58261（0.01 mg/kg，i.p.或i.v.）局部缺血后10分钟对血压正常的大鼠给药，24小时后测得的皮质梗塞体积显著减少（30% vs对照，p < 0.05）。当SCH 58261（0.01 mg/kg，i.p.）高血压大鼠心肌梗死体积缩小28%（P < 0.05）。SCH 58261在缺血后给药的神经保护特性表明，阻断A（2A）腺苷受体是减少脑损伤的潜在有用生物学靶点。NeuroReport 9：3955-3959（C）1998 Lippincott威廉姆斯和威尔金斯。
BLOCKADE of adenosine receptors can reduce cerebral infarct size in the model of global ischaemia. Using the potent and selective A(2A) adenosine receptor antagonist, SCH 58261, we assessed whether A(2A) receptors are involved in the neuronal damage following focal cerebral ischaemia as induced by occluding the left middle cerebral artery. SCH 58261 (0.01 mg/kg either i.p. or i.v.) administered to normotensive rats 10 min after ischaemia markedly reduced cortical infarct volume as measured 24 h later (30% vs controls, p < 0.05). Similar effects were observed when SCH 58261 (0.01 mg/kg, i.p.) was administered to hypertensive rats (28% infarct volume reduction vs controls, P < 0.05). Neuroprotective properties of SCH 58261 administered after ischaemia indicate that blockade of A(2A) adenosine receptors is a potentially useful biological target for the reduction of brain injury. NeuroReport 9: 3955-3959 (C) 1998 Lippincott Williams & Wilkins.