BILIRUBIN IS AN ANTIOXIDANT OF POSSIBLE PHYSIOLOGICAL IMPORTANCE
BILIRUBIN IS AN ANTIOXIDANT OF POSSIBLE PHYSIOLOGICAL IMPORTANCE
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DOI：
10.1126/science.3029864
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发表时间：
1987-02-27
期刊：
影响因子：
56.9
通讯作者：
AMES, BN
中科院分区：
文献类型：
--
作者：
STOCKER, R;YAMAMOTO, Y;AMES, BN
胆红素是哺乳动物血红素分解的最终产物，通常被认为是一种潜在的细胞毒性、脂溶性废物，需要排出体外。然而，它在这里表明，胆红素，在体外微摩尔浓度，有效地清除化学产生的过氧自由基在均匀的溶液或多层脂质体。胆红素的抗氧化活性随着实验氧浓度从20%（正常空气）降低到2%（生理相关浓度）而增加。此外，在2%氧下，在脂质体中，胆红素比α-胆红素更能抑制氧化。维生素E被认为是脂质过氧化的最佳抗氧化剂。这些数据支持胆红素作为一种生理性的、破坏链的抗氧化剂的“有益”作用的观点。
Bilirubin, the end product of heme catabolism in mammals, is generally regarded as a potentially cytotoxic, lipid-soluble waste product that needs to be excreted. However, it is shown here that bilirubin, at micromolar concentrations in vitro, efficiently scavenges peroxyl radicals generated chemically in either homogeneous solution or multilamellar liposomes. The antioxidant activity of bilirubin increases as the experimental concentration of oxygen is decreased from 20% (that of normal air) to 2% (physiologically relevant concentration). Furthermore, under 2% oxygen, in liposomes, bilirubin suppresses the oxidation more than .alpha.-tocopherol, which is regarded as the best antioxidant of lipid peroxidation. The data support the idea of a "beneficial" role for bilirubin as a physiological, chain-breaking antioxidant.