Profile of the JACC study
Profile of the JACC study
复制标题
DOI：
10.2188/jea.15.s4
复制
发表时间：
2005-03-01
影响因子：
4.7
通讯作者：
Iso, H
中科院分区：
文献类型：
--
作者：
Tamakoshi, A;Yoshimura, T;Iso, H
背景技术背景：一个大规模的人群为基础的队列研究将提供最好的证据之间的关系的生活方式和cancer.METHODS：日本合作队列研究（JACC研究）的癌症风险评估主办的教育，科学，体育和文化部的日本（文部省）成立，并进行了1988年至1990年在日本的45个地区。采用自填式问卷收集流行病学资料，包括人口学资料、既往病史、运动/体育活动、进食频率、吸烟和饮酒情况等。在45个地区中的37个地区，在筛选时从每个参与者中收集血液样本，以调查与血液中生化物质有关的癌症风险因素。将收集的血清分成3-5管（每管100-500 μ L）并储存在-80 ℃下。此外，在基线调查后约5年，在31个地区进行了关于生活方式变化的中期调查。如果可能的话，我们跟踪研究对象的死亡率，迁出率和癌症发病率（在24个地区）。结果：有127,477名参与者（54,032名男性和73,445名女性）登记参加了这项研究。其中，110，792例受试者（46，465例男性和64，327例女性），基线时年龄为40 - 79岁，有资格接受随访。从39，242名受试者中收集了血清，并对46，650名受试者进行了中期调查。结论：JACC研究为日本的癌症预防提供了有用的证据。
BACKGROUND: A large-scale population-based cohort study would offer the best evidence of a relation between lifestyle and cancer.METHODS: The Japan Collaborative Cohort Study (JACC Study) for Evaluation of Cancer Risk sponsored by the Ministry of Education, Science, Sports and Culture of Japan (Monbusho) was established and carried out from 1988 to 1990 in 45 areas in Japan. Epidemiological information, such as demographic information, past medical history, exercise/sports activities engaged in, frequency of food intake, smoking and alcohol drinking status and so on, was collected by a self-administered questionnaire. Blood samples were collected from each participant at screening in 37 out of 45 areas to investigate risk factors of cancer relating to biochemical substances in blood. Collected sera were divided into 3-5 tubes (100-500 mu L per tube) and stored at -80 degrees C. Additionally, about 5 years after the baseline survey, an interim survey regarding lifestyle changes was conducted in 31 areas. We followed the study subjects for mortality, move-outs, and cancer incidence, if possible (in 24 areas).RESULTS: There were 127,477 participants (54,032 men and 73,445 women) registered in the study. Of these, 110,792 subjects (46,465 men and 64,327 women), aged 40 to 79 years at baseline, were eligible for follow-up. Sera were stocked from 39,242 subjects, and interim survey was carried out on 46,650 subjects.CONCLUSIONS: The JACC Study provides useful evidence for cancer prevention in Japan.