Spousal recollections of early signs of primary progressive aphasia.
Spousal recollections of early signs of primary progressive aphasia.
复制标题
配偶对原发性进行性失语症早期症状的回忆。
DOI：
10.1111/1460-6984.12347
复制
发表时间：
2018
影响因子：
2.4
通讯作者：
D. Ames
中科院分区：
文献类型：
--
作者：
M. Pozzebon;J. Douglas;D. Ames
背景
虽然原发性进行性失语症（PPA）的特点是逐渐丧失语言和沟通能力，知识的最早出现的迹象宣布这种情况的发作是有限的。
旨在
探索配偶对PPA最早体征的回忆，并比较三种PPA变体最早感知症状的性质。
方法和程序
对13名配偶进行了深入访谈，重点是疾病发作的最早迹象，他们的伴侣被诊断患有PPA。根据DSM-5轻度神经认知障碍的标准，对配偶描述的最早回忆和观察进行分析和编码。然后将这些数据在三种PPA变体之间和内部进行比较。
结果和成果
配偶的回顾性报告表明，三种PPA变体（语义、逻辑开放和非流利）具有宣布疾病发作的特征。社会认知的变化在PPA的所有三种变体中都存在，但在疾病轨迹的不同点上。特别是，研究结果表明，PPA最初表现为语义变体PPA（svPPA）和逻辑缺失变体PPA（IvPPA）的社会认知的微妙变化，而不是当前诊断标准中定义的明显语言障碍。
结论和影响
了解在PPA的最早阶段感知到的症状的性质有可能为早期和准确的诊断和干预提供信息，以帮助那些患有这种疾病的人。
BACKGROUND
Although primary progressive aphasia (PPA) is characterized by progressive loss of language and communication skills, knowledge about the earliest emerging signs announcing the onset of this condition is limited.
AIMS
To explore spousal recollections regarding the earliest signs of PPA and to compare the nature of the earliest perceived symptoms across the three PPA variants.
METHODS & PROCEDURES
In-depth interviews focusing on the earliest signs of illness onset were conducted with 13 spouses whose partners were diagnosed with PPA. The earliest recollections and observations described by the spouses were analyzed and coded according to the DSM-5 criteria for a mild neurocognitive disorder. These data were then compared across and within each of the three PPA variants.
OUTCOMES & RESULTS
Spousal retrospective accounts indicated the three PPA variants (semantic, logopenic and non-fluent) had a signature profile announcing illness onset. Changes in social cognition presented in all three variants of PPA, but at different points in the illness trajectory. In particular, the findings suggest the possibility that PPA initially presents as subtle changes in social cognition for semantic variant PPA (svPPA) and logopenic variant PPA (IvPPA) rather than overt language impairments as defined in the current diagnostic criteria.
CONCLUSIONS & IMPLICATIONS
Understanding the nature of symptoms perceived in the earliest stages of PPA has potential to inform earlier and accurate diagnosis and interventions to assist those living with the illness.
影响因子：
14.5
作者：
Mesulam, M. -Marsel;Wieneke, Christina;Weintraub, Sandra
通讯作者：
Weintraub, Sandra