Diverse mechanisms in the generation of human beta-tubulin pseudogenes.
Diverse mechanisms in the generation of human beta-tubulin pseudogenes.
复制标题
人类β-微管蛋白假基因产生的多种机制。
DOI：
10.1126/science.6178164
复制
发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Cowan,NJ
中科院分区：
文献类型：
--
作者：
Wilde,CD;Crowther,CE;Cowan,NJ
描述了两个人β-微管蛋白假基因的序列。一种含有间插序列，但缺乏编码多肽链的55个N-末端氨基酸的序列。第二个没有内含子，但在其3′端有一个多腺苷酸信号和一个寡腺苷酸序列，它的侧翼是一个短的直接重复序列。这些序列是通过不同的机制产生的，包括可能涉及加工信使RNA的逆转录和互补DNA拷贝重新整合到基因组中的机制。
The sequence of two human β-tubulin pseudogenes is described. One contains an intervening sequence but lacks sequences encoding the 55N-terminal amino acids of the polypeptide chain. A second has no introns but has a polyadenylate signal and an oligoadenylate tract at its 3′ end, and it is flanked by a short direct repeat. These sequences have arisen by different mechanisms, including one that probably involves reverse transcription of a processed messenger RNA and reintegration of the complementary DNA copy into the genome.