Mendelian randomization in multiple sclerosis: A causal role for vitamin D and obesity?
Mendelian randomization in multiple sclerosis: A causal role for vitamin D and obesity?
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DOI：
10.1177/1352458517737373
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发表时间：
2018-01-01
影响因子：
5.8
通讯作者：
Richards, J. Brent
中科院分区：
文献类型：
--
作者：
Harroud, Adil;Richards, J. Brent
多发性硬化症 (MS) 的病因涉及遗传和环境因素的复杂相互作用。流行病学研究加深了我们对这些危险因素的理解，但仍然受到残留混杂因素和反向因果关系的可能性的限制，特别是在疾病发病时间未知的多发性硬化症中。孟德尔随机化 (MR) 使用遗传变异来研究可改变的暴露对结果的因果影响。这种方法避免了经典流行病学的一些局限性，可以加强因果推断。在这里，我们介绍MR的基本概念并回顾其对MS领域的贡献。事实上，一些使用 MR 的研究现已支持低维生素 D 水平和肥胖在 MS 发展中的因果作用。
The etiology of multiple sclerosis (MS) involves a complex interplay of genetic and environmental factors. Epidemiologic studies have furthered our understanding of these risk factors but remain limited by residual confounding and potential for reverse causation, particularly in MS where time of disease onset is not known. Mendelian randomization (MR) uses genetic variants to study the causal effect of modifiable exposures on an outcome. This method avoids some of the limitations of classical epidemiology and can strengthen causal inference. Here, we introduce the basic concepts of MR and review its contributions to the field of MS. Indeed, several studies using MR have now provided support for a causal role for low vitamin D level and obesity in the development of MS.