Down syndrome births in the United States from 1989 to 2001
Down syndrome births in the United States from 1989 to 2001
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DOI：
10.1016/j.ajog.2004.06.050
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发表时间：
2004-09-01
影响因子：
9.8
通讯作者：
Borgida, AF
中科院分区：
文献类型：
--
作者：
Egan, JFX;Benn, PA;Borgida, AF
目的：我们调查了1989年至2001年在美国观察到的和预期的唐氏综合征活产。研究设计：使用出生证明数据，我们记录了1989年至2001年母亲年龄特异性活产，并将其分层为15至34岁和35至49岁的妇女。我们估计了1989年至2001年唐氏综合症的活产率，假设没有终止妊娠。结果：1989 ~ 2001年，唐氏综合征的活产率预计增长1.32倍，但实际上却呈下降趋势。1989年，唐氏综合症的发病率比预期低15%，到1998年下降到51%。2001年，15至34岁的妇女受影响怀孕的人数减少了45%，而35至49岁的妇女则减少了53%。我们估计唐氏综合征活产从1989年的3962例下降到2001年的3654例。结论：尽管推迟或延长生育时间会导致唐氏综合征活产增加，但美国唐氏综合征活产减少。(C)2004年爱思唯尔公司All rights reserved.
Objective: We investigated the observed and expected Down syndrome livebirths in the US from 1989 to 2001.Study design: Using birth certificate data, we recorded maternal age-specific live births from 1989 to 2001, and stratified them by women 15 to 34 and 35 to 49 years old. We estimated Down syndrome live births from 1989 to 2001, assuming no terminations. We recorded Down syndrome live births by year from 1989 to 2001.Results: Despite an expected 1.32-fold increase in Down syndrome live birth rates from 1989 to 2001, Down syndrome live births actually declined. In 1989, the rate of Down syndrome cases was 15% lower than expected, decreasing to 51% by 1998. Women 15 to 34 had 45% fewer affected pregnancies in 2001, while women 35 to 49 had 53% fewer in 2001. We estimated that Down syndrome live births decreased from 3962 in 1989 to 3654 in 2001.Conclusion: Down syndrome live births declined in the US despite an expected increase caused by delayed or extended childbearing. (C) 2004 Elsevier Inc. All rights reserved.